Autophagy, a double-edged sword in hepatocarcinogenesis

Autophagy has opposite effects on hepatocarcinogenesis depending on whether it occurs before or after its onset. Autophagy prevents the initiation of hepatocarcinogenesis by suppressing oxidative stress and DNA damage. However, it also inhibits cell death and the expression of tumor suppressors to p...

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Detalles Bibliográficos
Autores principales: Tian, Yongjun, Wang, Linya, Ou, Jing-hsiung James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905348/
https://www.ncbi.nlm.nih.gov/pubmed/27308502
http://dx.doi.org/10.1080/23723556.2015.1004968
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author Tian, Yongjun
Wang, Linya
Ou, Jing-hsiung James
author_facet Tian, Yongjun
Wang, Linya
Ou, Jing-hsiung James
author_sort Tian, Yongjun
collection PubMed
description Autophagy has opposite effects on hepatocarcinogenesis depending on whether it occurs before or after its onset. Autophagy prevents the initiation of hepatocarcinogenesis by suppressing oxidative stress and DNA damage. However, it also inhibits cell death and the expression of tumor suppressors to promote tumor progression once hepatocarcinogenesis has been initiated.
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spelling pubmed-49053482016-06-15 Autophagy, a double-edged sword in hepatocarcinogenesis Tian, Yongjun Wang, Linya Ou, Jing-hsiung James Mol Cell Oncol Author's View Autophagy has opposite effects on hepatocarcinogenesis depending on whether it occurs before or after its onset. Autophagy prevents the initiation of hepatocarcinogenesis by suppressing oxidative stress and DNA damage. However, it also inhibits cell death and the expression of tumor suppressors to promote tumor progression once hepatocarcinogenesis has been initiated. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905348/ /pubmed/27308502 http://dx.doi.org/10.1080/23723556.2015.1004968 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Tian, Yongjun
Wang, Linya
Ou, Jing-hsiung James
Autophagy, a double-edged sword in hepatocarcinogenesis
title Autophagy, a double-edged sword in hepatocarcinogenesis
title_full Autophagy, a double-edged sword in hepatocarcinogenesis
title_fullStr Autophagy, a double-edged sword in hepatocarcinogenesis
title_full_unstemmed Autophagy, a double-edged sword in hepatocarcinogenesis
title_short Autophagy, a double-edged sword in hepatocarcinogenesis
title_sort autophagy, a double-edged sword in hepatocarcinogenesis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905348/
https://www.ncbi.nlm.nih.gov/pubmed/27308502
http://dx.doi.org/10.1080/23723556.2015.1004968
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AT wanglinya autophagyadoubleedgedswordinhepatocarcinogenesis
AT oujinghsiungjames autophagyadoubleedgedswordinhepatocarcinogenesis

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