WWOX guards genome stability by activating ATM

Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates w...

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Detalles Bibliográficos
Autores principales: Hazan, Idit, Abu-Odeh, Mohammad, Hofmann, Thomas G, Aqeilan, Rami I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905350/
https://www.ncbi.nlm.nih.gov/pubmed/27308504
http://dx.doi.org/10.1080/23723556.2015.1008288
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author Hazan, Idit
Abu-Odeh, Mohammad
Hofmann, Thomas G
Aqeilan, Rami I
author_facet Hazan, Idit
Abu-Odeh, Mohammad
Hofmann, Thomas G
Aqeilan, Rami I
author_sort Hazan, Idit
collection PubMed
description Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.
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spelling pubmed-49053502016-06-15 WWOX guards genome stability by activating ATM Hazan, Idit Abu-Odeh, Mohammad Hofmann, Thomas G Aqeilan, Rami I Mol Cell Oncol Commentary Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity. Taylor & Francis 2015-02-23 /pmc/articles/PMC4905350/ /pubmed/27308504 http://dx.doi.org/10.1080/23723556.2015.1008288 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Hazan, Idit
Abu-Odeh, Mohammad
Hofmann, Thomas G
Aqeilan, Rami I
WWOX guards genome stability by activating ATM
title WWOX guards genome stability by activating ATM
title_full WWOX guards genome stability by activating ATM
title_fullStr WWOX guards genome stability by activating ATM
title_full_unstemmed WWOX guards genome stability by activating ATM
title_short WWOX guards genome stability by activating ATM
title_sort wwox guards genome stability by activating atm
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905350/
https://www.ncbi.nlm.nih.gov/pubmed/27308504
http://dx.doi.org/10.1080/23723556.2015.1008288
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