WWOX guards genome stability by activating ATM

Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates w...

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Detalles Bibliográficos
Autores principales: Hazan, Idit, Abu-Odeh, Mohammad, Hofmann, Thomas G, Aqeilan, Rami I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905350/
https://www.ncbi.nlm.nih.gov/pubmed/27308504
http://dx.doi.org/10.1080/23723556.2015.1008288

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