Taspase 1: A protease with many biological surprises

Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFI...

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Detalles Bibliográficos
Autores principales: Niizuma, Hidetaka, Cheng, Emily H, Hsieh, James J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905357/
https://www.ncbi.nlm.nih.gov/pubmed/27308523
http://dx.doi.org/10.1080/23723556.2014.999513
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author Niizuma, Hidetaka
Cheng, Emily H
Hsieh, James J
author_facet Niizuma, Hidetaka
Cheng, Emily H
Hsieh, James J
author_sort Niizuma, Hidetaka
collection PubMed
description Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction” protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.
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spelling pubmed-49053572016-06-15 Taspase 1: A protease with many biological surprises Niizuma, Hidetaka Cheng, Emily H Hsieh, James J Mol Cell Oncol Author's View Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction” protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905357/ /pubmed/27308523 http://dx.doi.org/10.1080/23723556.2014.999513 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Niizuma, Hidetaka
Cheng, Emily H
Hsieh, James J
Taspase 1: A protease with many biological surprises
title Taspase 1: A protease with many biological surprises
title_full Taspase 1: A protease with many biological surprises
title_fullStr Taspase 1: A protease with many biological surprises
title_full_unstemmed Taspase 1: A protease with many biological surprises
title_short Taspase 1: A protease with many biological surprises
title_sort taspase 1: a protease with many biological surprises
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905357/
https://www.ncbi.nlm.nih.gov/pubmed/27308523
http://dx.doi.org/10.1080/23723556.2014.999513
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AT chengemilyh taspase1aproteasewithmanybiologicalsurprises
AT hsiehjamesj taspase1aproteasewithmanybiologicalsurprises

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