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Endosomal acidification inhibitors for the treatment of BRAF mutant tumors
Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphoryl...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905373/ https://www.ncbi.nlm.nih.gov/pubmed/27308590 http://dx.doi.org/10.1080/23723556.2015.1062073 |
| _version_ | 1782437254756564992 |
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| author | Espinosa, Lluís |
| author_facet | Espinosa, Lluís |
| author_sort | Espinosa, Lluís |
| collection | PubMed |
| description | Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphorylation of p45-IKKα and abolish the metastatic capacity of BRAF mutant cancer cells. |
| format | Online Article Text |
| id | pubmed-4905373 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49053732016-11-18 Endosomal acidification inhibitors for the treatment of BRAF mutant tumors Espinosa, Lluís Mol Cell Oncol Author's View Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphorylation of p45-IKKα and abolish the metastatic capacity of BRAF mutant cancer cells. Taylor & Francis 2015-11-18 /pmc/articles/PMC4905373/ /pubmed/27308590 http://dx.doi.org/10.1080/23723556.2015.1062073 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| spellingShingle | Author's View Espinosa, Lluís Endosomal acidification inhibitors for the treatment of BRAF mutant tumors |
| title | Endosomal acidification inhibitors for the treatment of BRAF mutant tumors |
| title_full | Endosomal acidification inhibitors for the treatment of BRAF mutant tumors |
| title_fullStr | Endosomal acidification inhibitors for the treatment of BRAF mutant tumors |
| title_full_unstemmed | Endosomal acidification inhibitors for the treatment of BRAF mutant tumors |
| title_short | Endosomal acidification inhibitors for the treatment of BRAF mutant tumors |
| title_sort | endosomal acidification inhibitors for the treatment of braf mutant tumors |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905373/ https://www.ncbi.nlm.nih.gov/pubmed/27308590 http://dx.doi.org/10.1080/23723556.2015.1062073 |
| work_keys_str_mv | AT espinosalluis endosomalacidificationinhibitorsforthetreatmentofbrafmutanttumors |