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Endosomal acidification inhibitors for the treatment of BRAF mutant tumors
Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphoryl...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905373/ https://www.ncbi.nlm.nih.gov/pubmed/27308590 http://dx.doi.org/10.1080/23723556.2015.1062073 |