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Endosomal acidification inhibitors for the treatment of BRAF mutant tumors

Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphoryl...

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Detalles Bibliográficos
Autor principal:	Espinosa, Lluís
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905373/ https://www.ncbi.nlm.nih.gov/pubmed/27308590 http://dx.doi.org/10.1080/23723556.2015.1062073

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