Different cell fates after mitotic slippage: From aneuploidy to polyploidy

The molecular mechanism responsible for cell fate after mitotic slippage remains unclear. We investigated the different postmitotic effects of aneuploidy versus polyploidy using chemical inhibitors of centromere-associated protein-E (CENP-E) and kinesin family member 11 (KIF11, also known as Eg5). A...

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Autor principal: Ohashi, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905391/
https://www.ncbi.nlm.nih.gov/pubmed/27308610
http://dx.doi.org/10.1080/23723556.2015.1088503
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author Ohashi, Akihiro
author_facet Ohashi, Akihiro
author_sort Ohashi, Akihiro
collection PubMed
description The molecular mechanism responsible for cell fate after mitotic slippage remains unclear. We investigated the different postmitotic effects of aneuploidy versus polyploidy using chemical inhibitors of centromere-associated protein-E (CENP-E) and kinesin family member 11 (KIF11, also known as Eg5). Aneuploidy caused substantial proteotoxic stress and DNA damage accompanied by p53-mediated postmitotic apoptosis, whereas polyploidy did not induce these antiproliferative effects.
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spelling pubmed-49053912016-10-06 Different cell fates after mitotic slippage: From aneuploidy to polyploidy Ohashi, Akihiro Mol Cell Oncol Author's View The molecular mechanism responsible for cell fate after mitotic slippage remains unclear. We investigated the different postmitotic effects of aneuploidy versus polyploidy using chemical inhibitors of centromere-associated protein-E (CENP-E) and kinesin family member 11 (KIF11, also known as Eg5). Aneuploidy caused substantial proteotoxic stress and DNA damage accompanied by p53-mediated postmitotic apoptosis, whereas polyploidy did not induce these antiproliferative effects. Taylor & Francis 2015-10-06 /pmc/articles/PMC4905391/ /pubmed/27308610 http://dx.doi.org/10.1080/23723556.2015.1088503 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Ohashi, Akihiro
Different cell fates after mitotic slippage: From aneuploidy to polyploidy
title Different cell fates after mitotic slippage: From aneuploidy to polyploidy
title_full Different cell fates after mitotic slippage: From aneuploidy to polyploidy
title_fullStr Different cell fates after mitotic slippage: From aneuploidy to polyploidy
title_full_unstemmed Different cell fates after mitotic slippage: From aneuploidy to polyploidy
title_short Different cell fates after mitotic slippage: From aneuploidy to polyploidy
title_sort different cell fates after mitotic slippage: from aneuploidy to polyploidy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905391/
https://www.ncbi.nlm.nih.gov/pubmed/27308610
http://dx.doi.org/10.1080/23723556.2015.1088503
work_keys_str_mv AT ohashiakihiro differentcellfatesaftermitoticslippagefromaneuploidytopolyploidy

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