Linking apoptosis to cancer metabolism: Another missing piece of JuNK

Cancer cells become dependent on aerobic glycolysis to sustain rapid proliferation and escape apoptosis. How this metabolic change, also known as the Warburg effect, is linked to apoptosis remains largely unknown. Our new data place c-Jun N-terminal kinase in the center of a hub regulating apoptosis...

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Detalles Bibliográficos
Autores principales: Papa, Salvatore, Bubici, Concetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905410/
https://www.ncbi.nlm.nih.gov/pubmed/27308628
http://dx.doi.org/10.1080/23723556.2015.1103398
Descripción
Sumario:Cancer cells become dependent on aerobic glycolysis to sustain rapid proliferation and escape apoptosis. How this metabolic change, also known as the Warburg effect, is linked to apoptosis remains largely unknown. Our new data place c-Jun N-terminal kinase in the center of a hub regulating apoptosis and cancer metabolism.

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