EglN2 positively regulates mitochondrial function in breast cancer

Oxygen sensing is associated with mitochondrial function. EglN2, which contributes to breast tumorigenesis as a prolyl hydroxylase, has recently been identified as a transcription co-activator through interaction with NRF1 and PGC1α to regulate mitochondrial function under conditions of normoxia and...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Zheng, Xingnan, Zhang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905419/
https://www.ncbi.nlm.nih.gov/pubmed/27308620
http://dx.doi.org/10.1080/23723556.2015.1120845
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author Zhang, Jing
Zheng, Xingnan
Zhang, Qing
author_facet Zhang, Jing
Zheng, Xingnan
Zhang, Qing
author_sort Zhang, Jing
collection PubMed
description Oxygen sensing is associated with mitochondrial function. EglN2, which contributes to breast tumorigenesis as a prolyl hydroxylase, has recently been identified as a transcription co-activator through interaction with NRF1 and PGC1α to regulate mitochondrial function under conditions of normoxia and hypoxia. FDXR is the important downstream target gene that mediates this regulation.
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spelling pubmed-49054192016-12-22 EglN2 positively regulates mitochondrial function in breast cancer Zhang, Jing Zheng, Xingnan Zhang, Qing Mol Cell Oncol Author's View Oxygen sensing is associated with mitochondrial function. EglN2, which contributes to breast tumorigenesis as a prolyl hydroxylase, has recently been identified as a transcription co-activator through interaction with NRF1 and PGC1α to regulate mitochondrial function under conditions of normoxia and hypoxia. FDXR is the important downstream target gene that mediates this regulation. Taylor & Francis 2015-12-22 /pmc/articles/PMC4905419/ /pubmed/27308620 http://dx.doi.org/10.1080/23723556.2015.1120845 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Zhang, Jing
Zheng, Xingnan
Zhang, Qing
EglN2 positively regulates mitochondrial function in breast cancer
title EglN2 positively regulates mitochondrial function in breast cancer
title_full EglN2 positively regulates mitochondrial function in breast cancer
title_fullStr EglN2 positively regulates mitochondrial function in breast cancer
title_full_unstemmed EglN2 positively regulates mitochondrial function in breast cancer
title_short EglN2 positively regulates mitochondrial function in breast cancer
title_sort egln2 positively regulates mitochondrial function in breast cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905419/
https://www.ncbi.nlm.nih.gov/pubmed/27308620
http://dx.doi.org/10.1080/23723556.2015.1120845
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