Differentiation therapy for glioblastoma – too many obstacles?

The therapeutic potential of differentiation therapy for glioblastoma will depend on the robustness and stability of the differentiated state. We recently reported several obstacles to bone morphogenetic protein (BMP)-induced differentiation therapy. Improved understanding of the mechanisms that tum...

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Detalles Bibliográficos
Autores principales: Carén, Helena, Beck, Stephan, Pollard, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905420/
https://www.ncbi.nlm.nih.gov/pubmed/27308621
http://dx.doi.org/10.1080/23723556.2015.1124174
Descripción
Sumario:The therapeutic potential of differentiation therapy for glioblastoma will depend on the robustness and stability of the differentiated state. We recently reported several obstacles to bone morphogenetic protein (BMP)-induced differentiation therapy. Improved understanding of the mechanisms that tumor cells use to escape differentiation commitment is urgently needed.

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