Differentiation therapy for glioblastoma – too many obstacles?

The therapeutic potential of differentiation therapy for glioblastoma will depend on the robustness and stability of the differentiated state. We recently reported several obstacles to bone morphogenetic protein (BMP)-induced differentiation therapy. Improved understanding of the mechanisms that tum...

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Detalles Bibliográficos
Autores principales: Carén, Helena, Beck, Stephan, Pollard, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905420/
https://www.ncbi.nlm.nih.gov/pubmed/27308621
http://dx.doi.org/10.1080/23723556.2015.1124174
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author Carén, Helena
Beck, Stephan
Pollard, Steven M.
author_facet Carén, Helena
Beck, Stephan
Pollard, Steven M.
author_sort Carén, Helena
collection PubMed
description The therapeutic potential of differentiation therapy for glioblastoma will depend on the robustness and stability of the differentiated state. We recently reported several obstacles to bone morphogenetic protein (BMP)-induced differentiation therapy. Improved understanding of the mechanisms that tumor cells use to escape differentiation commitment is urgently needed.
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spelling pubmed-49054202016-12-28 Differentiation therapy for glioblastoma – too many obstacles? Carén, Helena Beck, Stephan Pollard, Steven M. Mol Cell Oncol Author's View The therapeutic potential of differentiation therapy for glioblastoma will depend on the robustness and stability of the differentiated state. We recently reported several obstacles to bone morphogenetic protein (BMP)-induced differentiation therapy. Improved understanding of the mechanisms that tumor cells use to escape differentiation commitment is urgently needed. Taylor & Francis 2015-12-28 /pmc/articles/PMC4905420/ /pubmed/27308621 http://dx.doi.org/10.1080/23723556.2015.1124174 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Carén, Helena
Beck, Stephan
Pollard, Steven M.
Differentiation therapy for glioblastoma – too many obstacles?
title Differentiation therapy for glioblastoma – too many obstacles?
title_full Differentiation therapy for glioblastoma – too many obstacles?
title_fullStr Differentiation therapy for glioblastoma – too many obstacles?
title_full_unstemmed Differentiation therapy for glioblastoma – too many obstacles?
title_short Differentiation therapy for glioblastoma – too many obstacles?
title_sort differentiation therapy for glioblastoma – too many obstacles?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905420/
https://www.ncbi.nlm.nih.gov/pubmed/27308621
http://dx.doi.org/10.1080/23723556.2015.1124174
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