Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling

The tumor suppressor Smad4/DPC4 is an essential transcription factor in the TGF-β pathway that was previously thought to function constitutively. We recently reported that Smad4 activity and stability are directly regulated by 2 major signaling pathways, RTK/MAPK and Wnt/GSK3. Here we examine the mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Demagny, Hadrien, De Robertis, Edward M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905428/
https://www.ncbi.nlm.nih.gov/pubmed/27308623
http://dx.doi.org/10.4161/23723556.2014.989133
_version_ 1782437257761783808
author Demagny, Hadrien
De Robertis, Edward M
author_facet Demagny, Hadrien
De Robertis, Edward M
author_sort Demagny, Hadrien
collection PubMed
description The tumor suppressor Smad4/DPC4 is an essential transcription factor in the TGF-β pathway that was previously thought to function constitutively. We recently reported that Smad4 activity and stability are directly regulated by 2 major signaling pathways, RTK/MAPK and Wnt/GSK3. Here we examine the molecular, cellular, and potential therapeutic significance of these findings.
format Online
Article
Text
id pubmed-4905428
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49054282016-06-15 Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling Demagny, Hadrien De Robertis, Edward M Mol Cell Oncol Author's View The tumor suppressor Smad4/DPC4 is an essential transcription factor in the TGF-β pathway that was previously thought to function constitutively. We recently reported that Smad4 activity and stability are directly regulated by 2 major signaling pathways, RTK/MAPK and Wnt/GSK3. Here we examine the molecular, cellular, and potential therapeutic significance of these findings. Taylor & Francis 2015-01-30 /pmc/articles/PMC4905428/ /pubmed/27308623 http://dx.doi.org/10.4161/23723556.2014.989133 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Demagny, Hadrien
De Robertis, Edward M
Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling
title Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling
title_full Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling
title_fullStr Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling
title_full_unstemmed Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling
title_short Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling
title_sort smad4/dpc4: a barrier against tumor progression driven by rtk/ras/erk and wnt/gsk3 signaling
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905428/
https://www.ncbi.nlm.nih.gov/pubmed/27308623
http://dx.doi.org/10.4161/23723556.2014.989133
work_keys_str_mv AT demagnyhadrien smad4dpc4abarrieragainsttumorprogressiondrivenbyrtkraserkandwntgsk3signaling
AT derobertisedwardm smad4dpc4abarrieragainsttumorprogressiondrivenbyrtkraserkandwntgsk3signaling

Ejemplares similares