Speed matters: How subtle changes in DNA end resection rate affect repair

The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the molecular level is less well understood. By developing a new high-resolution, single-molecule technique, we have now shown that BRCA1 accelerates the processing of DNA breaks that su...

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Detalles Bibliográficos
Autores principales: Huertas, Pablo, Cruz-García, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905430/
https://www.ncbi.nlm.nih.gov/pubmed/27308460
http://dx.doi.org/10.4161/23723556.2014.982964
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author Huertas, Pablo
Cruz-García, Andrés
author_facet Huertas, Pablo
Cruz-García, Andrés
author_sort Huertas, Pablo
collection PubMed
description The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the molecular level is less well understood. By developing a new high-resolution, single-molecule technique, we have now shown that BRCA1 accelerates the processing of DNA breaks that subsequently engage in homologous recombination.
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spelling pubmed-49054302016-06-15 Speed matters: How subtle changes in DNA end resection rate affect repair Huertas, Pablo Cruz-García, Andrés Mol Cell Oncol Author's Views The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the molecular level is less well understood. By developing a new high-resolution, single-molecule technique, we have now shown that BRCA1 accelerates the processing of DNA breaks that subsequently engage in homologous recombination. Taylor & Francis 2015-05-06 /pmc/articles/PMC4905430/ /pubmed/27308460 http://dx.doi.org/10.4161/23723556.2014.982964 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Huertas, Pablo
Cruz-García, Andrés
Speed matters: How subtle changes in DNA end resection rate affect repair
title Speed matters: How subtle changes in DNA end resection rate affect repair
title_full Speed matters: How subtle changes in DNA end resection rate affect repair
title_fullStr Speed matters: How subtle changes in DNA end resection rate affect repair
title_full_unstemmed Speed matters: How subtle changes in DNA end resection rate affect repair
title_short Speed matters: How subtle changes in DNA end resection rate affect repair
title_sort speed matters: how subtle changes in dna end resection rate affect repair
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905430/
https://www.ncbi.nlm.nih.gov/pubmed/27308460
http://dx.doi.org/10.4161/23723556.2014.982964
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