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MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency

Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC), and marginal ZD is prevalent in humans. In rats, marked-ZD (3 mg Zn/kg diet) induces a proliferative esophagus with a 5-microRNA signature (miR-31, -223, -21, -146b, -146a) and promotes ESCC. Here we report that mo...

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Detalles Bibliográficos
Autores principales:	Fong, Louise Y., Taccioli, Cristian, Jing, Ruiyan, Smalley, Karl J., Alder, Hansjuerg, Jiang, Yubao, Fadda, Paolo, Farber, John L., Croce, Carlo M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905434/ https://www.ncbi.nlm.nih.gov/pubmed/26918602 http://dx.doi.org/10.18632/oncotarget.7561

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