MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5

The thrombopoietin receptor (MPL) has been shown to be mutated (MPL W515L) in myelofibrosis and thrombocytosis yet new approaches to treat this disorder are still required. We have previously shown that transcriptome and proteomic effects do not correlate well in oncogene-mediated leukemogenesis. We...

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Detalles Bibliográficos
Autores principales: Whetton, Anthony D., Azmi, Norhaida Che, Pearson, Stella, Jaworska, Ewa, Zhang, Liqun, Blance, Rognvald, Kendall, Alexandra C., Nicolaou, Anna, Taylor, Samuel, Williamson, Andrew J.K., Pierce, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905435/
https://www.ncbi.nlm.nih.gov/pubmed/26919114
http://dx.doi.org/10.18632/oncotarget.7639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905435/
https://www.ncbi.nlm.nih.gov/pubmed/26919114
http://dx.doi.org/10.18632/oncotarget.7639

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