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Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells
Acinar-to-ductal metaplasia (ADM) occurring in cerulein-mediated pancreatitis or in oncogenic Kras-driven pancreatic cancer development is accompanied by extensive changes in the transcriptional program. In this process, acinar cells shut down the expression of acinar specific differentiation genes...
Autores principales: | Benitz, Simone, Regel, Ivonne, Reinhard, Tobias, Popp, Anna, Schäffer, Isabell, Raulefs, Susanne, Kong, Bo, Esposito, Irene, Michalski, Christoph W., Kleeff, Jörg |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905483/ https://www.ncbi.nlm.nih.gov/pubmed/26716510 http://dx.doi.org/10.18632/oncotarget.6717 |
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