hMENA(11a), a hMENA isoform sending survival signals

Human MENA(11a )(hMENA(11a)), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a nove...

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Detalles Bibliográficos
Autores principales: Trono, Paola, Di Modugno, Francesca, Nisticò, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905527/
https://www.ncbi.nlm.nih.gov/pubmed/27308605
http://dx.doi.org/10.1080/23723556.2015.1083648
Descripción
Sumario:Human MENA(11a )(hMENA(11a)), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA(11a) as a marker of HER3 activation and resistance to phosphatidylinositol-3-kinase inhibition therapies.

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