hMENA(11a), a hMENA isoform sending survival signals

Human MENA(11a )(hMENA(11a)), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a nove...

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Detalles Bibliográficos
Autores principales: Trono, Paola, Di Modugno, Francesca, Nisticò, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905527/
https://www.ncbi.nlm.nih.gov/pubmed/27308605
http://dx.doi.org/10.1080/23723556.2015.1083648
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author Trono, Paola
Di Modugno, Francesca
Nisticò, Paola
author_facet Trono, Paola
Di Modugno, Francesca
Nisticò, Paola
author_sort Trono, Paola
collection PubMed
description Human MENA(11a )(hMENA(11a)), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA(11a) as a marker of HER3 activation and resistance to phosphatidylinositol-3-kinase inhibition therapies.
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spelling pubmed-49055272016-08-27 hMENA(11a), a hMENA isoform sending survival signals Trono, Paola Di Modugno, Francesca Nisticò, Paola Mol Cell Oncol Author's View Human MENA(11a )(hMENA(11a)), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA(11a) as a marker of HER3 activation and resistance to phosphatidylinositol-3-kinase inhibition therapies. Taylor & Francis 2015-08-27 /pmc/articles/PMC4905527/ /pubmed/27308605 http://dx.doi.org/10.1080/23723556.2015.1083648 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Trono, Paola
Di Modugno, Francesca
Nisticò, Paola
hMENA(11a), a hMENA isoform sending survival signals
title hMENA(11a), a hMENA isoform sending survival signals
title_full hMENA(11a), a hMENA isoform sending survival signals
title_fullStr hMENA(11a), a hMENA isoform sending survival signals
title_full_unstemmed hMENA(11a), a hMENA isoform sending survival signals
title_short hMENA(11a), a hMENA isoform sending survival signals
title_sort hmena(11a), a hmena isoform sending survival signals
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905527/
https://www.ncbi.nlm.nih.gov/pubmed/27308605
http://dx.doi.org/10.1080/23723556.2015.1083648
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