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Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer
Genetic mutation, chromosomal rearrangement and copy number amplification are common mechanisms responsible for generating gain-of-function, cancer-causing alterations. Here we report a new mechanism by which premature cleavage and polyadenylation (pPA) of RNA can produce an oncogenic protein. We id...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905742/ https://www.ncbi.nlm.nih.gov/pubmed/27205883 http://dx.doi.org/10.7554/eLife.14730 |