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Autoimmune Myopathies: Where Do We Stand?

Autoimmune diseases (AIDs) as a whole represent a major health concern and remain a medical and scientific challenge. Some of them, such as multiple sclerosis or type 1 diabetes, have been actively investigated for many decades. Autoimmune myopathies (AIMs), also referred to as idiopathic inflammato...

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Autores principales: Simon, Jean-Philippe, Marie, Isabelle, Jouen, Fabienne, Boyer, Olivier, Martinet, Jérémie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905946/
https://www.ncbi.nlm.nih.gov/pubmed/27379096
http://dx.doi.org/10.3389/fimmu.2016.00234
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author Simon, Jean-Philippe
Marie, Isabelle
Jouen, Fabienne
Boyer, Olivier
Martinet, Jérémie
author_facet Simon, Jean-Philippe
Marie, Isabelle
Jouen, Fabienne
Boyer, Olivier
Martinet, Jérémie
author_sort Simon, Jean-Philippe
collection PubMed
description Autoimmune diseases (AIDs) as a whole represent a major health concern and remain a medical and scientific challenge. Some of them, such as multiple sclerosis or type 1 diabetes, have been actively investigated for many decades. Autoimmune myopathies (AIMs), also referred to as idiopathic inflammatory myopathies or myositis, represent a group of very severe AID for which we have a more limited pathophysiological knowledge. AIM encompass a group of, individually rare but collectively not so uncommon, diseases characterized by symmetrical proximal muscle weakness, increased serum muscle enzymes such as creatine kinase, myopathic changes on electromyography, and several typical histological patterns on muscle biopsy, including the presence of inflammatory cell infiltrates in muscle tissue. Importantly, some AIMs are strongly related to cancer. Here, we review the current knowledge on the most prevalent forms of AIM and, notably, the diagnostic contribution of autoantibodies.
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spelling pubmed-49059462016-07-04 Autoimmune Myopathies: Where Do We Stand? Simon, Jean-Philippe Marie, Isabelle Jouen, Fabienne Boyer, Olivier Martinet, Jérémie Front Immunol Immunology Autoimmune diseases (AIDs) as a whole represent a major health concern and remain a medical and scientific challenge. Some of them, such as multiple sclerosis or type 1 diabetes, have been actively investigated for many decades. Autoimmune myopathies (AIMs), also referred to as idiopathic inflammatory myopathies or myositis, represent a group of very severe AID for which we have a more limited pathophysiological knowledge. AIM encompass a group of, individually rare but collectively not so uncommon, diseases characterized by symmetrical proximal muscle weakness, increased serum muscle enzymes such as creatine kinase, myopathic changes on electromyography, and several typical histological patterns on muscle biopsy, including the presence of inflammatory cell infiltrates in muscle tissue. Importantly, some AIMs are strongly related to cancer. Here, we review the current knowledge on the most prevalent forms of AIM and, notably, the diagnostic contribution of autoantibodies. Frontiers Media S.A. 2016-06-14 /pmc/articles/PMC4905946/ /pubmed/27379096 http://dx.doi.org/10.3389/fimmu.2016.00234 Text en Copyright © 2016 Simon, Marie, Jouen, Boyer and Martinet. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Simon, Jean-Philippe
Marie, Isabelle
Jouen, Fabienne
Boyer, Olivier
Martinet, Jérémie
Autoimmune Myopathies: Where Do We Stand?
title Autoimmune Myopathies: Where Do We Stand?
title_full Autoimmune Myopathies: Where Do We Stand?
title_fullStr Autoimmune Myopathies: Where Do We Stand?
title_full_unstemmed Autoimmune Myopathies: Where Do We Stand?
title_short Autoimmune Myopathies: Where Do We Stand?
title_sort autoimmune myopathies: where do we stand?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905946/
https://www.ncbi.nlm.nih.gov/pubmed/27379096
http://dx.doi.org/10.3389/fimmu.2016.00234
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