Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)

RAS mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of RAS mutation status (both KRAS and NRAS), and it is good practice to include BRAF. In Non-Small Cell Lung Cancer (NSCLC)...

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Detalles Bibliográficos
Autor principal: Cree, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906127/
https://www.ncbi.nlm.nih.gov/pubmed/27335808
http://dx.doi.org/10.1016/j.bdq.2016.05.001
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author Cree, Ian A.
author_facet Cree, Ian A.
author_sort Cree, Ian A.
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description RAS mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of RAS mutation status (both KRAS and NRAS), and it is good practice to include BRAF. In Non-Small Cell Lung Cancer (NSCLC) and melanoma, assessment of RAS mutation status can be helpful in triaging patient samples for more extensive testing. This mini-review will discuss the role of PCR methods in providing rapid diagnostic information for cancer patients.
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spelling pubmed-49061272016-06-22 Diagnostic RAS mutation analysis by polymerase chain reaction (PCR) Cree, Ian A. Biomol Detect Quantif Research Paper RAS mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of RAS mutation status (both KRAS and NRAS), and it is good practice to include BRAF. In Non-Small Cell Lung Cancer (NSCLC) and melanoma, assessment of RAS mutation status can be helpful in triaging patient samples for more extensive testing. This mini-review will discuss the role of PCR methods in providing rapid diagnostic information for cancer patients. Elsevier 2016-06-06 /pmc/articles/PMC4906127/ /pubmed/27335808 http://dx.doi.org/10.1016/j.bdq.2016.05.001 Text en © 2016 Elsevier GmbH. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Cree, Ian A.
Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_full Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_fullStr Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_full_unstemmed Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_short Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_sort diagnostic ras mutation analysis by polymerase chain reaction (pcr)
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906127/
https://www.ncbi.nlm.nih.gov/pubmed/27335808
http://dx.doi.org/10.1016/j.bdq.2016.05.001
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