Cargando…

Vascular Fibrosis in Aging and Hypertension: Molecular Mechanisms and Clinical Implications

Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and arterial stiffening. Vascular stiffness results...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harvey, Adam, Montezano, Augusto C., Lopes, Rheure Alves, Rios, Francisco, Touyz, Rhian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pulsus Group 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906153/ https://www.ncbi.nlm.nih.gov/pubmed/27118293 http://dx.doi.org/10.1016/j.cjca.2016.02.070

Ejemplares similares

Vascular biology of ageing—Implications in hypertension
por: Harvey, Adam, et al.
Publicado: (2015)

Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: The aldosterone-mineralocorticoid receptor-Nox1 axis
por: Harvey, Adam P., et al.
Publicado: (2017)

Vascular smooth muscle contraction in hypertension
por: Touyz, Rhian M, et al.
Publicado: (2018)

Role of PARP and TRPM2 in VEGF Inhibitor‐Induced Vascular Dysfunction
por: Neves, Karla B., et al.
Publicado: (2023)

Oxidative Stress: A Unifying Paradigm in Hypertension
por: Touyz, Rhian M., et al.
Publicado: (2020)

Vascular Biology of Superoxide-Generating NADPH Oxidase 5—Implications in Hypertension and Cardiovascular Disease
por: Touyz, Rhian M., et al.
Publicado: (2019)

Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications
por: Lucas-Herald, Angela K., et al.
Publicado: (2017)

Vasoprotective effects of NOX4 are mediated via polymerase and transient receptor potential melastatin 2 cation channels in endothelial cells
por: Alves-Lopes, Rheure, et al.
Publicado: (2023)

Sex steroids receptors, hypertension, and vascular ageing
por: Connelly, Paul J., et al.
Publicado: (2021)

Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension
por: Alves-Lopes, Rhéure, et al.
Publicado: (2021)

Redox signaling, Nox5 and vascular remodeling in hypertension
por: Montezano, Augusto C., et al.
Publicado: (2015)

Central role of c-Src in NOX5- mediated redox signalling in vascular smooth muscle cells in human hypertension
por: Camargo, Livia L, et al.
Publicado: (2021)

Muscarinic Receptor Type-3 in Hypertension and Cholinergic-Adrenergic Crosstalk: Genetic Insights and Potential for New Antihypertensive Targets
por: Alves-Lopes, Rhéure, et al.
Publicado: (2019)

Nicotinamide Adenine Dinucleotide Phosphate Oxidase–Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension
por: Hood, Katie Y., et al.
Publicado: (2016)

SUN-551 Impaired Vascular Relaxation and Altered eNOS Regulation in Boys with Hypospadias
por: Lucas-Herald, Angela K, et al.
Publicado: (2020)

NADPH Oxidase 5 Is a Pro‐Contractile Nox Isoform and a Point of Cross‐Talk for Calcium and Redox Signaling‐Implications in Vascular Function
por: Montezano, Augusto C., et al.
Publicado: (2018)

ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease
por: Kuriakose, Jithin, et al.
Publicado: (2021)

NOX5: Molecular biology and pathophysiology
por: Touyz, Rhian M., et al.
Publicado: (2019)

Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function
por: Zou, Zhi-Guo, et al.
Publicado: (2020)

ER stress and Rho kinase activation underlie the vasculopathy of CADASIL
por: Neves, Karla B., et al.
Publicado: (2019)

Notch3 signalling and vascular remodelling in pulmonary arterial hypertension
por: Morris, Hannah E., et al.
Publicado: (2019)

Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice
por: Neves, Karla Bianca, et al.
Publicado: (2018)

Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury
por: Neves, Karla B, et al.
Publicado: (2019)

TRPM7, Magnesium, and Signaling
por: Zou, Zhi-Guo, et al.
Publicado: (2019)

Vascular dysfunction and increased cardiovascular risk in hypospadias
por: Lucas-Herald, Angela K, et al.
Publicado: (2022)

Serotonin Signaling Through the 5-HT(1B) Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension
por: Hood, Katie Y., et al.
Publicado: (2017)

Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways
por: Morris, Hannah E., et al.
Publicado: (2023)

Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells
por: Anagnostopoulou, Aikaterini, et al.
Publicado: (2020)

Microparticles Induce Cell Cycle Arrest Through Redox-Sensitive Processes in Endothelial Cells: Implications in Vascular Senescence
por: Burger, Dylan, et al.
Publicado: (2012)

TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt
por: Rios, Francisco J., et al.
Publicado: (2022)

Vascular mechanisms of post-COVID-19 conditions: Rho-kinase is a novel target for therapy
por: Sykes, Robert A, et al.
Publicado: (2023)

Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms
por: Petrie, John R., et al.
Publicado: (2018)

Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis
por: Rios, Francisco J, et al.
Publicado: (2020)

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication
por: Montezano, Augusto C., et al.
Publicado: (2023)

Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress
por: Bruder-Nascimento, Thiago, et al.
Publicado: (2019)

Comprehensive Characterization of the Vascular Effects of Cisplatin-Based Chemotherapy in Patients With Testicular Cancer
por: Cameron, Alan C., et al.
Publicado: (2020)

Vascular toxicities with VEGF inhibitor therapies–focus on hypertension and arterial thrombotic events
por: Touyz, Rhian M., et al.
Publicado: (2018)

Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
por: Rossitto, Giacomo, et al.
Publicado: (2020)

Testosterone and Vascular Function in Aging
por: Lopes, Rhéure A. M., et al.
Publicado: (2012)

An Interaction of Renin-Angiotensin and Kallikrein-Kinin Systems Contributes to Vascular Hypertrophy in Angiotensin II-Induced Hypertension: In Vivo and In Vitro Studies
por: Ceravolo, Graziela S., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_b89b769gsfrlv6n9u4ta7bvlct