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Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience

Purpose. Neuroendocrine neoplasms (NENs) of the esophagus are very uncommon with only a few studies published worldwide. Studies on clinical profile, management, and outcomes are very uncommon. Methods. We report the largest single institution retrospective review of 43 patients of pure esophageal N...

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Autores principales: Babu Kanakasetty, Govind, Dasappa, Loknatha, Lakshmaiah, Kuntegowdanahalli Chinnagiriyappa, Kamath, Mangesh, Jacob, Linu Abraham, Mallekavu, Suresh Babu, Rajeev, Lakkavalli Krishnappa, Haleshappa, Rudresha Antapura, Kadabur Nagendrappa, Lokesh, Saldanha, Smitha Carol, Kumar, Rekha V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906204/
https://www.ncbi.nlm.nih.gov/pubmed/27340404
http://dx.doi.org/10.1155/2016/2402417
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author Babu Kanakasetty, Govind
Dasappa, Loknatha
Lakshmaiah, Kuntegowdanahalli Chinnagiriyappa
Kamath, Mangesh
Jacob, Linu Abraham
Mallekavu, Suresh Babu
Rajeev, Lakkavalli Krishnappa
Haleshappa, Rudresha Antapura
Kadabur Nagendrappa, Lokesh
Saldanha, Smitha Carol
Kumar, Rekha V.
author_facet Babu Kanakasetty, Govind
Dasappa, Loknatha
Lakshmaiah, Kuntegowdanahalli Chinnagiriyappa
Kamath, Mangesh
Jacob, Linu Abraham
Mallekavu, Suresh Babu
Rajeev, Lakkavalli Krishnappa
Haleshappa, Rudresha Antapura
Kadabur Nagendrappa, Lokesh
Saldanha, Smitha Carol
Kumar, Rekha V.
author_sort Babu Kanakasetty, Govind
collection PubMed
description Purpose. Neuroendocrine neoplasms (NENs) of the esophagus are very uncommon with only a few studies published worldwide. Studies on clinical profile, management, and outcomes are very uncommon. Methods. We report the largest single institution retrospective review of 43 patients of pure esophageal NENs out of our registry of gastrointestinal neuroendocrine tumors treated between 2005 and 2014. Data on the incidence, tumor location, clinical symptoms, stage at presentation, grading, treatment protocol, and treatment outcomes was collected and analyzed. Results. Among 1293 cases of esophageal cancers, pure esophageal NENs were diagnosed in 43 cases. The mean patient age was 55.8 years. The male : female ratio was 1.5 : 1. 81.4% of the tumors were located in the lower third of the esophagus and gastroesophageal junction. Neuroendocrine carcinomas (NEC; G3) accounted for the vast majority of NENs (83.7%). 53.5% patients were Stage IV and 32.5% were Stage III at presentation. The combined median survival of stages II and III patients was 18.25 months, with treatment. The median survival of treated patients with metastatic disease was 6.5 months. Conclusion. Esophageal NENs most commonly were neuroendocrine carcinomas, presented in metastatic stage and were associated with poor prognosis. Grade 2 (G2) tumors had better outcomes than NEC (G3). In nonmetastatic disease, presence of lymph node metastasis and unresectable disease had poorer outcomes.
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spelling pubmed-49062042016-06-23 Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience Babu Kanakasetty, Govind Dasappa, Loknatha Lakshmaiah, Kuntegowdanahalli Chinnagiriyappa Kamath, Mangesh Jacob, Linu Abraham Mallekavu, Suresh Babu Rajeev, Lakkavalli Krishnappa Haleshappa, Rudresha Antapura Kadabur Nagendrappa, Lokesh Saldanha, Smitha Carol Kumar, Rekha V. J Oncol Research Article Purpose. Neuroendocrine neoplasms (NENs) of the esophagus are very uncommon with only a few studies published worldwide. Studies on clinical profile, management, and outcomes are very uncommon. Methods. We report the largest single institution retrospective review of 43 patients of pure esophageal NENs out of our registry of gastrointestinal neuroendocrine tumors treated between 2005 and 2014. Data on the incidence, tumor location, clinical symptoms, stage at presentation, grading, treatment protocol, and treatment outcomes was collected and analyzed. Results. Among 1293 cases of esophageal cancers, pure esophageal NENs were diagnosed in 43 cases. The mean patient age was 55.8 years. The male : female ratio was 1.5 : 1. 81.4% of the tumors were located in the lower third of the esophagus and gastroesophageal junction. Neuroendocrine carcinomas (NEC; G3) accounted for the vast majority of NENs (83.7%). 53.5% patients were Stage IV and 32.5% were Stage III at presentation. The combined median survival of stages II and III patients was 18.25 months, with treatment. The median survival of treated patients with metastatic disease was 6.5 months. Conclusion. Esophageal NENs most commonly were neuroendocrine carcinomas, presented in metastatic stage and were associated with poor prognosis. Grade 2 (G2) tumors had better outcomes than NEC (G3). In nonmetastatic disease, presence of lymph node metastasis and unresectable disease had poorer outcomes. Hindawi Publishing Corporation 2016 2016-05-31 /pmc/articles/PMC4906204/ /pubmed/27340404 http://dx.doi.org/10.1155/2016/2402417 Text en Copyright © 2016 Govind Babu Kanakasetty et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Babu Kanakasetty, Govind
Dasappa, Loknatha
Lakshmaiah, Kuntegowdanahalli Chinnagiriyappa
Kamath, Mangesh
Jacob, Linu Abraham
Mallekavu, Suresh Babu
Rajeev, Lakkavalli Krishnappa
Haleshappa, Rudresha Antapura
Kadabur Nagendrappa, Lokesh
Saldanha, Smitha Carol
Kumar, Rekha V.
Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience
title Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience
title_full Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience
title_fullStr Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience
title_full_unstemmed Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience
title_short Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience
title_sort clinicopathological profile of pure neuroendocrine neoplasms of the esophagus: a south indian center experience
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906204/
https://www.ncbi.nlm.nih.gov/pubmed/27340404
http://dx.doi.org/10.1155/2016/2402417
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