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Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats
Hypercholesterolemia is a well-known etiological factor for cardiovascular disease and a common symptom of most types of metabolic disorders. Camellia japonica is a traditional garden plant, and its flower and seed have been used as a base oil of traditional cosmetics in East Asia. The present study...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906218/ https://www.ncbi.nlm.nih.gov/pubmed/27340422 http://dx.doi.org/10.1155/2016/9679867 |
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author | Lee, Hyun-Ho Paudel, Keshav Raj Jeong, Jieun Wi, An-Jin Park, Whoa-Shig Kim, Dong-Wook Oak, Min-Ho |
author_facet | Lee, Hyun-Ho Paudel, Keshav Raj Jeong, Jieun Wi, An-Jin Park, Whoa-Shig Kim, Dong-Wook Oak, Min-Ho |
author_sort | Lee, Hyun-Ho |
collection | PubMed |
description | Hypercholesterolemia is a well-known etiological factor for cardiovascular disease and a common symptom of most types of metabolic disorders. Camellia japonica is a traditional garden plant, and its flower and seed have been used as a base oil of traditional cosmetics in East Asia. The present study was carried out to evaluate the effect of C. japonica fruit extracts (CJF) in a high fat diet- (HFD-) induced hypercholesterolemic rat model. CJF was administered orally at three different doses: 100, 400, and 800 mg·kg(−1)·day(−1) (CJF 100, 400, and 800, resp.). Our results showed that CJF possessed strong cholesterol-lowering potency as indicated by the decrease in serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL), accompanied by an increase in serum high-density lipoprotein (HDL). Furthermore, CJF reduced serum lipid peroxidation by suppressing the formation of thiobarbituric acid reactive substance. In addition, oil red O (ORO) staining of rat arteries showed decreased lipid-positive staining in the CJF-treated groups compared to the control HFD group. Taken together, these results suggest that CJF could be a potent herbal therapeutic option and source of a functional food for the prevention and treatment of atherosclerosis and other diseases associated with hypercholesterolemia. |
format | Online Article Text |
id | pubmed-4906218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49062182016-06-23 Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats Lee, Hyun-Ho Paudel, Keshav Raj Jeong, Jieun Wi, An-Jin Park, Whoa-Shig Kim, Dong-Wook Oak, Min-Ho Evid Based Complement Alternat Med Research Article Hypercholesterolemia is a well-known etiological factor for cardiovascular disease and a common symptom of most types of metabolic disorders. Camellia japonica is a traditional garden plant, and its flower and seed have been used as a base oil of traditional cosmetics in East Asia. The present study was carried out to evaluate the effect of C. japonica fruit extracts (CJF) in a high fat diet- (HFD-) induced hypercholesterolemic rat model. CJF was administered orally at three different doses: 100, 400, and 800 mg·kg(−1)·day(−1) (CJF 100, 400, and 800, resp.). Our results showed that CJF possessed strong cholesterol-lowering potency as indicated by the decrease in serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL), accompanied by an increase in serum high-density lipoprotein (HDL). Furthermore, CJF reduced serum lipid peroxidation by suppressing the formation of thiobarbituric acid reactive substance. In addition, oil red O (ORO) staining of rat arteries showed decreased lipid-positive staining in the CJF-treated groups compared to the control HFD group. Taken together, these results suggest that CJF could be a potent herbal therapeutic option and source of a functional food for the prevention and treatment of atherosclerosis and other diseases associated with hypercholesterolemia. Hindawi Publishing Corporation 2016 2016-05-31 /pmc/articles/PMC4906218/ /pubmed/27340422 http://dx.doi.org/10.1155/2016/9679867 Text en Copyright © 2016 Hyun-Ho Lee et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lee, Hyun-Ho Paudel, Keshav Raj Jeong, Jieun Wi, An-Jin Park, Whoa-Shig Kim, Dong-Wook Oak, Min-Ho Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats |
title | Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats |
title_full | Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats |
title_fullStr | Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats |
title_full_unstemmed | Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats |
title_short | Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats |
title_sort | antiatherogenic effect of camellia japonica fruit extract in high fat diet-fed rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906218/ https://www.ncbi.nlm.nih.gov/pubmed/27340422 http://dx.doi.org/10.1155/2016/9679867 |
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