Structural Mechanisms of Voltage Sensing in G Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs) form the largest superfamily of membrane proteins and one-third of all drug targets in humans. A number of recent studies have reported evidence for substantial voltage regulation of GPCRs. However, the structural basis of GPCR voltage sensing has remained enigmat...

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Detalles Bibliográficos
Autores principales: Vickery, Owen N., Machtens, Jan-Philipp, Tamburrino, Giulia, Seeliger, Daniel, Zachariae, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Theory
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906246/
https://www.ncbi.nlm.nih.gov/pubmed/27210286
http://dx.doi.org/10.1016/j.str.2016.04.007

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