GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid availability relies on the capacity of GCN2 to sense the increased levels of uncharged tRNAs u...

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Detalles Bibliográficos
Autores principales: Averous, Julien, Lambert-Langlais, Sarah, Mesclon, Florent, Carraro, Valérie, Parry, Laurent, Jousse, Céline, Bruhat, Alain, Maurin, Anne-Catherine, Pierre, Philippe, Proud, Christopher G., Fafournoux, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906353/
https://www.ncbi.nlm.nih.gov/pubmed/27297692
http://dx.doi.org/10.1038/srep27698

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