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Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome

Lipidomics of human blood plasma is an emerging biomarker discovery approach that compares lipid profiles under pathological and physiologically normal conditions, but how a healthy lipidome varies within the population is poorly understood. By quantifying 281 molecular species from 27 major lipid c...

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Autores principales: Sales, Susanne, Graessler, Juergen, Ciucci, Sara, Al-Atrib, Rania, Vihervaara, Terhi, Schuhmann, Kai, Kauhanen, Dimple, Sysi-Aho, Marko, Bornstein, Stefan R., Bickle, Marc, Cannistraci, Carlo V., Ekroos, Kim, Shevchenko, Andrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906355/
https://www.ncbi.nlm.nih.gov/pubmed/27295977
http://dx.doi.org/10.1038/srep27710
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author Sales, Susanne
Graessler, Juergen
Ciucci, Sara
Al-Atrib, Rania
Vihervaara, Terhi
Schuhmann, Kai
Kauhanen, Dimple
Sysi-Aho, Marko
Bornstein, Stefan R.
Bickle, Marc
Cannistraci, Carlo V.
Ekroos, Kim
Shevchenko, Andrej
author_facet Sales, Susanne
Graessler, Juergen
Ciucci, Sara
Al-Atrib, Rania
Vihervaara, Terhi
Schuhmann, Kai
Kauhanen, Dimple
Sysi-Aho, Marko
Bornstein, Stefan R.
Bickle, Marc
Cannistraci, Carlo V.
Ekroos, Kim
Shevchenko, Andrej
author_sort Sales, Susanne
collection PubMed
description Lipidomics of human blood plasma is an emerging biomarker discovery approach that compares lipid profiles under pathological and physiologically normal conditions, but how a healthy lipidome varies within the population is poorly understood. By quantifying 281 molecular species from 27 major lipid classes in the plasma of 71 healthy young Caucasians whose 35 clinical blood test and anthropometric indices matched the medical norm, we provided a comprehensive, expandable and clinically relevant resource of reference molar concentrations of individual lipids. We established that gender is a major lipidomic factor, whose impact is strongly enhanced by hormonal contraceptives and mediated by sex hormone-binding globulin. In lipidomics epidemiological studies should avoid mixed-gender cohorts and females taking hormonal contraceptives should be considered as a separate sub-cohort. Within a gender-restricted cohort lipidomics revealed a compositional signature that indicates the predisposition towards an early development of metabolic syndrome in ca. 25% of healthy male individuals suggesting a healthy plasma lipidome as resource for early biomarker discovery.
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spelling pubmed-49063552016-06-15 Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome Sales, Susanne Graessler, Juergen Ciucci, Sara Al-Atrib, Rania Vihervaara, Terhi Schuhmann, Kai Kauhanen, Dimple Sysi-Aho, Marko Bornstein, Stefan R. Bickle, Marc Cannistraci, Carlo V. Ekroos, Kim Shevchenko, Andrej Sci Rep Article Lipidomics of human blood plasma is an emerging biomarker discovery approach that compares lipid profiles under pathological and physiologically normal conditions, but how a healthy lipidome varies within the population is poorly understood. By quantifying 281 molecular species from 27 major lipid classes in the plasma of 71 healthy young Caucasians whose 35 clinical blood test and anthropometric indices matched the medical norm, we provided a comprehensive, expandable and clinically relevant resource of reference molar concentrations of individual lipids. We established that gender is a major lipidomic factor, whose impact is strongly enhanced by hormonal contraceptives and mediated by sex hormone-binding globulin. In lipidomics epidemiological studies should avoid mixed-gender cohorts and females taking hormonal contraceptives should be considered as a separate sub-cohort. Within a gender-restricted cohort lipidomics revealed a compositional signature that indicates the predisposition towards an early development of metabolic syndrome in ca. 25% of healthy male individuals suggesting a healthy plasma lipidome as resource for early biomarker discovery. Nature Publishing Group 2016-06-14 /pmc/articles/PMC4906355/ /pubmed/27295977 http://dx.doi.org/10.1038/srep27710 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Sales, Susanne
Graessler, Juergen
Ciucci, Sara
Al-Atrib, Rania
Vihervaara, Terhi
Schuhmann, Kai
Kauhanen, Dimple
Sysi-Aho, Marko
Bornstein, Stefan R.
Bickle, Marc
Cannistraci, Carlo V.
Ekroos, Kim
Shevchenko, Andrej
Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome
title Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome
title_full Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome
title_fullStr Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome
title_full_unstemmed Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome
title_short Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome
title_sort gender, contraceptives and individual metabolic predisposition shape a healthy plasma lipidome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906355/
https://www.ncbi.nlm.nih.gov/pubmed/27295977
http://dx.doi.org/10.1038/srep27710
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