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New Glycoconjugates for the Treatment of Diseases Related to Metal Dyshomeostasis
Metal dyshomeostasis is involved in several pathologies, making metal ions promising therapeutic targets. Conjugating 8‐hydroxyquinolines with sugars gave rise to novel derivatives with improved solubility, selectivity, and multifunctionality. Biological evaluation of these compounds suggests they h...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906504/ https://www.ncbi.nlm.nih.gov/pubmed/27308206 http://dx.doi.org/10.1002/open.201500155 |
| Sumario: | Metal dyshomeostasis is involved in several pathologies, making metal ions promising therapeutic targets. Conjugating 8‐hydroxyquinolines with sugars gave rise to novel derivatives with improved solubility, selectivity, and multifunctionality. Biological evaluation of these compounds suggests they have potential as therapeutic agents in diseases related to metal dyshomeostasis.[Image: see text] |
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