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Increased autophagic response in a population of metastatic breast cancer cells
Breast cancer cells are heterogeneous in their ability to invade and fully metastasize, and thus also in their capacity to survive the numerous stresses encountered throughout the multiple steps of the metastatic cascade. Considering the role of autophagy as a survival response to stress, the presen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906619/ https://www.ncbi.nlm.nih.gov/pubmed/27347175 http://dx.doi.org/10.3892/ol.2016.4613 |
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author | LI, YI LIBBY, EMILY FALK LEWIS, MONICA J. LIU, JIANZHONG SHACKA, JOHN J. HURST, DOUGLAS R. |
author_facet | LI, YI LIBBY, EMILY FALK LEWIS, MONICA J. LIU, JIANZHONG SHACKA, JOHN J. HURST, DOUGLAS R. |
author_sort | LI, YI |
collection | PubMed |
description | Breast cancer cells are heterogeneous in their ability to invade and fully metastasize, and thus also in their capacity to survive the numerous stresses encountered throughout the multiple steps of the metastatic cascade. Considering the role of autophagy as a survival response to stress, the present study hypothesized that distinct populations of breast cancer cells may possess an altered autophagic capacity that influences their metastatic potential. It was observed that a metastatic breast cancer cell line, MDA-MB-231, that was sensitive to autophagic induction additionally possessed the ability to proliferate following nutrient deprivation. Furthermore, a selected subpopulation of these cells that survived multiple exposures to starvation conditions demonstrated a heightened response to autophagic induction compared to their parent cells. Although this subpopulation maintained a more grape-like pattern in three-dimensional culture compared to the extended spikes of the parent population, autophagic induction in this subpopulation elicited an invasive phenotype with extended spikes. Taken together, these results suggest that autophagic induction may contribute to the ability of distinct breast cancer cell populations to survive and invade. |
format | Online Article Text |
id | pubmed-4906619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-49066192016-06-24 Increased autophagic response in a population of metastatic breast cancer cells LI, YI LIBBY, EMILY FALK LEWIS, MONICA J. LIU, JIANZHONG SHACKA, JOHN J. HURST, DOUGLAS R. Oncol Lett Articles Breast cancer cells are heterogeneous in their ability to invade and fully metastasize, and thus also in their capacity to survive the numerous stresses encountered throughout the multiple steps of the metastatic cascade. Considering the role of autophagy as a survival response to stress, the present study hypothesized that distinct populations of breast cancer cells may possess an altered autophagic capacity that influences their metastatic potential. It was observed that a metastatic breast cancer cell line, MDA-MB-231, that was sensitive to autophagic induction additionally possessed the ability to proliferate following nutrient deprivation. Furthermore, a selected subpopulation of these cells that survived multiple exposures to starvation conditions demonstrated a heightened response to autophagic induction compared to their parent cells. Although this subpopulation maintained a more grape-like pattern in three-dimensional culture compared to the extended spikes of the parent population, autophagic induction in this subpopulation elicited an invasive phenotype with extended spikes. Taken together, these results suggest that autophagic induction may contribute to the ability of distinct breast cancer cell populations to survive and invade. D.A. Spandidos 2016-07 2016-05-24 /pmc/articles/PMC4906619/ /pubmed/27347175 http://dx.doi.org/10.3892/ol.2016.4613 Text en Copyright: © Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles LI, YI LIBBY, EMILY FALK LEWIS, MONICA J. LIU, JIANZHONG SHACKA, JOHN J. HURST, DOUGLAS R. Increased autophagic response in a population of metastatic breast cancer cells |
title | Increased autophagic response in a population of metastatic breast cancer cells |
title_full | Increased autophagic response in a population of metastatic breast cancer cells |
title_fullStr | Increased autophagic response in a population of metastatic breast cancer cells |
title_full_unstemmed | Increased autophagic response in a population of metastatic breast cancer cells |
title_short | Increased autophagic response in a population of metastatic breast cancer cells |
title_sort | increased autophagic response in a population of metastatic breast cancer cells |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906619/ https://www.ncbi.nlm.nih.gov/pubmed/27347175 http://dx.doi.org/10.3892/ol.2016.4613 |
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