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Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats
A sexually dimorphic spinal gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord, which projects to the lower spinal centers, controls erection and ejaculation in rats. However, little is known about the postnatal development of this system. In this study, we therefore examined the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japan Academy
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906813/ https://www.ncbi.nlm.nih.gov/pubmed/26860455 http://dx.doi.org/10.2183/pjab.92.69 |
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author | KATAYAMA, Nao OTI, Takumi TAKANAMI, Keiko SAKAMOTO, Tatsuya SAKAMOTO, Hirotaka |
author_facet | KATAYAMA, Nao OTI, Takumi TAKANAMI, Keiko SAKAMOTO, Tatsuya SAKAMOTO, Hirotaka |
author_sort | KATAYAMA, Nao |
collection | PubMed |
description | A sexually dimorphic spinal gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord, which projects to the lower spinal centers, controls erection and ejaculation in rats. However, little is known about the postnatal development of this system. In this study, we therefore examined the postnatal development of the male-dominant spinal GRP system and its sexual differentiation in rats using immunohistochemistry. Our results show that male-dominant expression of GRP is prominent from the onset of puberty and that sexually dimorphism persists into adulthood. These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord. |
format | Online Article Text |
id | pubmed-4906813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Japan Academy |
record_format | MEDLINE/PubMed |
spelling | pubmed-49068132016-07-07 Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats KATAYAMA, Nao OTI, Takumi TAKANAMI, Keiko SAKAMOTO, Tatsuya SAKAMOTO, Hirotaka Proc Jpn Acad Ser B Phys Biol Sci Original Article A sexually dimorphic spinal gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord, which projects to the lower spinal centers, controls erection and ejaculation in rats. However, little is known about the postnatal development of this system. In this study, we therefore examined the postnatal development of the male-dominant spinal GRP system and its sexual differentiation in rats using immunohistochemistry. Our results show that male-dominant expression of GRP is prominent from the onset of puberty and that sexually dimorphism persists into adulthood. These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord. The Japan Academy 2016-02-10 /pmc/articles/PMC4906813/ /pubmed/26860455 http://dx.doi.org/10.2183/pjab.92.69 Text en © 2016 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article KATAYAMA, Nao OTI, Takumi TAKANAMI, Keiko SAKAMOTO, Tatsuya SAKAMOTO, Hirotaka Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats |
title | Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats |
title_full | Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats |
title_fullStr | Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats |
title_full_unstemmed | Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats |
title_short | Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats |
title_sort | postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906813/ https://www.ncbi.nlm.nih.gov/pubmed/26860455 http://dx.doi.org/10.2183/pjab.92.69 |
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