Cargando…

Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt/β-catenin pathway

Icariin (ICA), the main active flavonoid glucoside isolated from Herba Epimedii, has been shown to prevent postmenopausal bone loss in vitro. However, the mechanisms by which ICA prevents bone loss in vivo remain poorly understood. In the present study, the effect of ICA in an ovariectomized (OVX) r...

Descripción completa

Detalles Bibliográficos
Autores principales:	CHEN, GUANGMING, WANG, CHAOPENG, WANG, JIEFANG, YIN, SUJUAN, GAO, HAN, XIANG, LU, LIU, HENGRUI, XIONG, YINQUAN, WANG, PANPAN, ZHU, XIAOFENG, YANG, LI, ZHANG, RONGHUA
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906828/ https://www.ncbi.nlm.nih.gov/pubmed/27347050 http://dx.doi.org/10.3892/etm.2016.3333

Ejemplares similares

Icariin improves osteoporosis, inhibits the expression of PPARγ, C/EBPα, FABP4 mRNA, N1ICD and jagged1 proteins, and increases Notch2 mRNA in ovariectomized rats
por: Liu, Hengrui, et al.
Publicado: (2017)

Wnt-Signaling-Mediated Antiosteoporotic Activity of Porcine Placenta Hydrolysates in Ovariectomized Rats
por: Ko, Byoung-Seob, et al.
Publicado: (2012)

Antiosteoporotic effects of Polycan in combination with calcium lactate-gluconate in ovariectomized rats
por: CHOI, JAE-SUK, et al.
Publicado: (2014)

The Antiosteoporotic Activity of Central-Icaritin (CIT) on Bone Metabolism of Ovariectomized Rats
por: Jiang, Jun, et al.
Publicado: (2014)

Icariin Promotes Fracture Healing in Ovariectomized Rats
por: Zhang, Yong, et al.
Publicado: (2020)

Inhibitory effect of icariin on osteosarcoma cell proliferation via the Wnt/β-catenin signaling pathway
por: Ren, Yuxin, et al.
Publicado: (2018)

Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/β-catenin signaling pathway in vivo and in vitro
por: Wang, Junhua, et al.
Publicado: (2016)

Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wnt/β-Catenin-BMP Signaling
por: Li, Xiao-Feng, et al.
Publicado: (2013)

Osteocyte Wnt/β-catenin pathway activation upon mechanical loading is altered in ovariectomized mice
por: Jackson, Erica, et al.
Publicado: (2021)

Icariin Promotes the Osteogenesis of Bone Marrow Mesenchymal Stem Cells through Regulating Sclerostin and Activating the Wnt/β-Catenin Signaling Pathway
por: Gao, Jianliang, et al.
Publicado: (2021)

Antiosteoporotic activity of phytoestrogen-rich fraction separated from ethanol extract of aerial parts of Cissus quadrangularis in ovariectomized rats
por: Aswar, Urmila M., et al.
Publicado: (2012)

Heat-Killed Lacticaseibacillus paracasei GMNL-653 Exerts Antiosteoporotic Effects by Restoring the Gut Microbiota Dysbiosis in Ovariectomized Mice
por: Jhong, Jhih-Hua, et al.
Publicado: (2022)

Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer
por: Yang, Gang, et al.
Publicado: (2018)

Comparative Effects of Er-Xian Decoction, Epimedium Herbs, and Icariin with Estrogen on Bone and Reproductive Tissue in Ovariectomized Rats
por: Xue, Liming, et al.
Publicado: (2012)

miR-330–5p in Small Extracellular Vesicles Derived From Plastrum testudinis-Preconditioned Bone Mesenchymal Stem Cells Attenuates Osteogenesis by Modulating Wnt/β-Catenin Signaling
por: Li, Xiaoyun, et al.
Publicado: (2021)

Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degeneration in ovariectomized rats and enhance Wnt/β-catenin pathway activity
por: Jia, Haobo, et al.
Publicado: (2016)

Evaluation of Osteogenesis and Angiogenesis of Icariin in Local Controlled Release and Systemic Delivery for Calvarial Defect in Ovariectomized Rats
por: Wu, Yuqiong, et al.
Publicado: (2017)

Effects of Icariin on Modulating Gut Microbiota and Regulating Metabolite Alterations to Prevent Bone Loss in Ovariectomized Rat Model
por: Wang, Shanshan, et al.
Publicado: (2022)

Wnt/β-Catenin Signaling and Obesity
por: Chen, Na, et al.
Publicado: (2018)

The Combination of β-Asarone and Icariin Inhibits Amyloid-β and Reverses Cognitive Deficits by Promoting Mitophagy in Models of Alzheimer's Disease
por: Wang, Nanbu, et al.
Publicado: (2021)

Nigella sativa: A Potential Antiosteoporotic Agent
por: Shuid, Ahmad Nazrun, et al.
Publicado: (2012)

Icariin attenuates the tumor growth by targeting miR-1-3p/TNKS2/Wnt/β-catenin signaling axis in ovarian cancer
por: Fu, Yanjin, et al.
Publicado: (2022)

Downregulation of miR-146a inhibits osteoporosis in the jaws of ovariectomized rats by regulating the Wnt/β-catenin signaling pathway
por: Liu, Hua, et al.
Publicado: (2021)

Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells
por: Wang, Ronghua, et al.
Publicado: (2015)

Potential Antiosteoporotic Agents from Plants: A Comprehensive Review
por: Jia, Min, et al.
Publicado: (2012)

KCTD1 Suppresses Canonical Wnt Signaling Pathway by Enhancing β-catenin Degradation
por: Li, Xinxin, et al.
Publicado: (2014)

Wnt/β-Catenin Signaling in Liver Cancers
por: Wang, Wenhui, et al.
Publicado: (2019)

Toosendanin inhibits adipogenesis by activating Wnt/β-catenin signaling
por: Chen, Tian-xing, et al.
Publicado: (2018)

Isolation of Antiosteoporotic Compounds from Seeds of Sophora japonica
por: Abdallah, Hossam M., et al.
Publicado: (2014)

The protective effect of icariin and phosphorylated icariin against LPS-induced intestinal goblet cell dysfunction
por: Xiong, Wen, et al.
Publicado: (2019)

Targeting the Wnt/β-catenin signaling pathway in cancer
por: Zhang, Ya, et al.
Publicado: (2020)

Wnt/β-catenin signaling in cancers and targeted therapies
por: Yu, Fanyuan, et al.
Publicado: (2021)

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer
por: Yao, Hanhui, et al.
Publicado: (2022)

WNKs in Wnt/β-catenin signaling
por: Serysheva, Ekatherina, et al.
Publicado: (2014)

Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-κB and Wnt/β-catenin pathways
por: Li, Chunyang, et al.
Publicado: (2021)

Antiosteoporotic Effect of Combined Extract of Morus alba and Polygonum odoratum
por: Sungkamanee, Sudarat, et al.
Publicado: (2014)

Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts
por: Wu, Yan-Bin, et al.
Publicado: (2009)

Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1–42)-Induced Rat Model of Alzheimer's Disease
por: Sheng, Chenxia, et al.
Publicado: (2017)

Metformin activates Wnt/β-catenin for the treatment of diabetic osteoporosis
por: Huang, Xiaopeng, et al.
Publicado: (2022)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
por: Lin, Chung-Ming, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ufiqnj7tnahavi75fkcfhutq91