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NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR

Rift Valley fever virus (RVFV, family Bunyaviridae, genus Phlebovirus) is a relevant pathogen of both humans and livestock in Africa. The nonstructural protein NSs is a major virulence factor known to suppress the type I interferon (IFN) response by inhibiting host cell transcription and by proteaso...

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Detalles Bibliográficos
Autores principales:	Kainulainen, Markus, Lau, Simone, Samuel, Charles E., Hornung, Veit, Weber, Friedemann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907219/ https://www.ncbi.nlm.nih.gov/pubmed/27122577 http://dx.doi.org/10.1128/JVI.00016-16

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