A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking

JJX12 is an engineered bispecific antibody against ricin, a member of the medically important A-B family of toxins that exploits retrograde transport as means to gain entry into the cytosol of target cells. JJX12 consists of RTA-D10, a camelid single variable domain (V(H)H) antibody directed against...

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Detalles Bibliográficos
Autores principales: Herrera, Cristina, Klokk, Tove Irene, Cole, Richard, Sandvig, Kirsten, Mantis, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907443/
https://www.ncbi.nlm.nih.gov/pubmed/27300140
http://dx.doi.org/10.1371/journal.pone.0156893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907443/
https://www.ncbi.nlm.nih.gov/pubmed/27300140
http://dx.doi.org/10.1371/journal.pone.0156893

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