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Phylogenetic Characteristics of Anthrax Outbreaks in Liaoning Province, China, 2001-2015

Anthrax is a continuous threat in China, especially in rural regions. In July 2015, an anthrax outbreak occurred in Xifeng County, Liaoning Province. A total of 10 cutaneous anthrax cases were reported, with 210 people under medical observation. In this study, the general characteristics of human an...

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Autores principales: Mao, Lingling, Zhang, Enmin, Wang, Zijiang, Li, Yan, Zhou, Hang, Liu, Xuesheng, Zhang, Huijuan, Cai, Hong, Liang, Xudong, Sun, Yingwei, Zhang, Zhikai, Li, Wei, Yao, Wenqing, Wei, Jianchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907462/
https://www.ncbi.nlm.nih.gov/pubmed/27299730
http://dx.doi.org/10.1371/journal.pone.0157496
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author Mao, Lingling
Zhang, Enmin
Wang, Zijiang
Li, Yan
Zhou, Hang
Liu, Xuesheng
Zhang, Huijuan
Cai, Hong
Liang, Xudong
Sun, Yingwei
Zhang, Zhikai
Li, Wei
Yao, Wenqing
Wei, Jianchun
author_facet Mao, Lingling
Zhang, Enmin
Wang, Zijiang
Li, Yan
Zhou, Hang
Liu, Xuesheng
Zhang, Huijuan
Cai, Hong
Liang, Xudong
Sun, Yingwei
Zhang, Zhikai
Li, Wei
Yao, Wenqing
Wei, Jianchun
author_sort Mao, Lingling
collection PubMed
description Anthrax is a continuous threat in China, especially in rural regions. In July 2015, an anthrax outbreak occurred in Xifeng County, Liaoning Province. A total of 10 cutaneous anthrax cases were reported, with 210 people under medical observation. In this study, the general characteristics of human anthrax outbreak occurred in Liaoning Province were described, and all cases were caused by butchering and contacting sick animal. Meanwhile, the phylogenetic relationship between outbreak-related isolates/samples of the year 2015 and previous Bacillus anthracis strains was analyzed by means of canonical single nucleotide polymorphisms (canSNP), multiple-locus variable-number tandem repeat analysis (MLVA) with 15 markers and single-nucleotide repeats (SNR) analysis. There are two canSNP subgroups found in Liaoning, A.Br.001/002 and A.Br.Ames, and a total of six MLVA 15 genotypes and five SNR genotypes were observed. The strain collected from anthrax outbreak in Xifeng County in 2015 was classified as A.Br.001/002 subgroup and identified as MLVA15-29 genotype, with same SNR profile (CL10: 17, CL12: 15, CL33: 29, and CL35: 13). So we conclude that the same clone of B.anthracis caused the anthrax outbreak in Xifeng County in 2015, and this clone is different to previous isolates. Strengthening public health education in China is one of the most important measures to prevent and control anthrax.
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spelling pubmed-49074622016-07-18 Phylogenetic Characteristics of Anthrax Outbreaks in Liaoning Province, China, 2001-2015 Mao, Lingling Zhang, Enmin Wang, Zijiang Li, Yan Zhou, Hang Liu, Xuesheng Zhang, Huijuan Cai, Hong Liang, Xudong Sun, Yingwei Zhang, Zhikai Li, Wei Yao, Wenqing Wei, Jianchun PLoS One Research Article Anthrax is a continuous threat in China, especially in rural regions. In July 2015, an anthrax outbreak occurred in Xifeng County, Liaoning Province. A total of 10 cutaneous anthrax cases were reported, with 210 people under medical observation. In this study, the general characteristics of human anthrax outbreak occurred in Liaoning Province were described, and all cases were caused by butchering and contacting sick animal. Meanwhile, the phylogenetic relationship between outbreak-related isolates/samples of the year 2015 and previous Bacillus anthracis strains was analyzed by means of canonical single nucleotide polymorphisms (canSNP), multiple-locus variable-number tandem repeat analysis (MLVA) with 15 markers and single-nucleotide repeats (SNR) analysis. There are two canSNP subgroups found in Liaoning, A.Br.001/002 and A.Br.Ames, and a total of six MLVA 15 genotypes and five SNR genotypes were observed. The strain collected from anthrax outbreak in Xifeng County in 2015 was classified as A.Br.001/002 subgroup and identified as MLVA15-29 genotype, with same SNR profile (CL10: 17, CL12: 15, CL33: 29, and CL35: 13). So we conclude that the same clone of B.anthracis caused the anthrax outbreak in Xifeng County in 2015, and this clone is different to previous isolates. Strengthening public health education in China is one of the most important measures to prevent and control anthrax. Public Library of Science 2016-06-14 /pmc/articles/PMC4907462/ /pubmed/27299730 http://dx.doi.org/10.1371/journal.pone.0157496 Text en © 2016 Mao et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mao, Lingling
Zhang, Enmin
Wang, Zijiang
Li, Yan
Zhou, Hang
Liu, Xuesheng
Zhang, Huijuan
Cai, Hong
Liang, Xudong
Sun, Yingwei
Zhang, Zhikai
Li, Wei
Yao, Wenqing
Wei, Jianchun
Phylogenetic Characteristics of Anthrax Outbreaks in Liaoning Province, China, 2001-2015
title Phylogenetic Characteristics of Anthrax Outbreaks in Liaoning Province, China, 2001-2015
title_full Phylogenetic Characteristics of Anthrax Outbreaks in Liaoning Province, China, 2001-2015
title_fullStr Phylogenetic Characteristics of Anthrax Outbreaks in Liaoning Province, China, 2001-2015
title_full_unstemmed Phylogenetic Characteristics of Anthrax Outbreaks in Liaoning Province, China, 2001-2015
title_short Phylogenetic Characteristics of Anthrax Outbreaks in Liaoning Province, China, 2001-2015
title_sort phylogenetic characteristics of anthrax outbreaks in liaoning province, china, 2001-2015
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907462/
https://www.ncbi.nlm.nih.gov/pubmed/27299730
http://dx.doi.org/10.1371/journal.pone.0157496
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