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From micro- to nanostructured implantable device for local anesthetic delivery

Local anesthetics block the transmission of painful stimuli to the brain by acting on ion channels of nociceptor fibers, and find application in the management of acute and chronic pain. Despite the key role they play in modern medicine, their cardio and neurotoxicity (together with their short half...

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Autores principales: Zorzetto, Laura, Brambilla, Paola, Marcello, Elena, Bloise, Nora, De Gregori, Manuela, Cobianchi, Lorenzo, Peloso, Andrea, Allegri, Massimo, Visai, Livia, Petrini, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907738/
https://www.ncbi.nlm.nih.gov/pubmed/27354799
http://dx.doi.org/10.2147/IJN.S99028
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author Zorzetto, Laura
Brambilla, Paola
Marcello, Elena
Bloise, Nora
De Gregori, Manuela
Cobianchi, Lorenzo
Peloso, Andrea
Allegri, Massimo
Visai, Livia
Petrini, Paola
author_facet Zorzetto, Laura
Brambilla, Paola
Marcello, Elena
Bloise, Nora
De Gregori, Manuela
Cobianchi, Lorenzo
Peloso, Andrea
Allegri, Massimo
Visai, Livia
Petrini, Paola
author_sort Zorzetto, Laura
collection PubMed
description Local anesthetics block the transmission of painful stimuli to the brain by acting on ion channels of nociceptor fibers, and find application in the management of acute and chronic pain. Despite the key role they play in modern medicine, their cardio and neurotoxicity (together with their short half-life) stress the need for developing implantable devices for tailored local drug release, with the aim of counterbalancing their side effects and prolonging their pharmacological activity. This review discusses the evolution of the physical forms of local anesthetic delivery systems during the past decades. Depending on the use of different biocompatible materials (degradable polyesters, thermosensitive hydrogels, and liposomes and hydrogels from natural polymers) and manufacturing processes, these systems can be classified as films or micro- or nanostructured devices. We analyze and summarize the production techniques according to this classification, focusing on their relative advantages and disadvantages. The most relevant trend reported in this work highlights the effort of moving from microstructured to nanostructured systems, with the aim of reaching a scale comparable to the biological environment. Improved intracellular penetration compared to microstructured systems, indeed, provides specific drug absorption into the targeted tissue and can lead to an enhancement of its bioavailability and retention time. Nanostructured systems are realized by the modification of existing manufacturing processes (interfacial deposition and nanoprecipitation for degradable polyester particles and high- or low-temperature homogenization for liposomes) or development of novel strategies (electrospun matrices and nanogels). The high surface-to-volume ratio that characterizes nanostructured devices often leads to a burst drug release. This drawback needs to be addressed to fully exploit the advantage of the interaction between the target tissues and the drug: possible strategies could involve specific binding between the drug and the material chosen for the device, and a multiscale approach to reach a tailored, prolonged drug release.
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spelling pubmed-49077382016-06-28 From micro- to nanostructured implantable device for local anesthetic delivery Zorzetto, Laura Brambilla, Paola Marcello, Elena Bloise, Nora De Gregori, Manuela Cobianchi, Lorenzo Peloso, Andrea Allegri, Massimo Visai, Livia Petrini, Paola Int J Nanomedicine Review Local anesthetics block the transmission of painful stimuli to the brain by acting on ion channels of nociceptor fibers, and find application in the management of acute and chronic pain. Despite the key role they play in modern medicine, their cardio and neurotoxicity (together with their short half-life) stress the need for developing implantable devices for tailored local drug release, with the aim of counterbalancing their side effects and prolonging their pharmacological activity. This review discusses the evolution of the physical forms of local anesthetic delivery systems during the past decades. Depending on the use of different biocompatible materials (degradable polyesters, thermosensitive hydrogels, and liposomes and hydrogels from natural polymers) and manufacturing processes, these systems can be classified as films or micro- or nanostructured devices. We analyze and summarize the production techniques according to this classification, focusing on their relative advantages and disadvantages. The most relevant trend reported in this work highlights the effort of moving from microstructured to nanostructured systems, with the aim of reaching a scale comparable to the biological environment. Improved intracellular penetration compared to microstructured systems, indeed, provides specific drug absorption into the targeted tissue and can lead to an enhancement of its bioavailability and retention time. Nanostructured systems are realized by the modification of existing manufacturing processes (interfacial deposition and nanoprecipitation for degradable polyester particles and high- or low-temperature homogenization for liposomes) or development of novel strategies (electrospun matrices and nanogels). The high surface-to-volume ratio that characterizes nanostructured devices often leads to a burst drug release. This drawback needs to be addressed to fully exploit the advantage of the interaction between the target tissues and the drug: possible strategies could involve specific binding between the drug and the material chosen for the device, and a multiscale approach to reach a tailored, prolonged drug release. Dove Medical Press 2016-06-08 /pmc/articles/PMC4907738/ /pubmed/27354799 http://dx.doi.org/10.2147/IJN.S99028 Text en © 2016 Zorzetto et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Zorzetto, Laura
Brambilla, Paola
Marcello, Elena
Bloise, Nora
De Gregori, Manuela
Cobianchi, Lorenzo
Peloso, Andrea
Allegri, Massimo
Visai, Livia
Petrini, Paola
From micro- to nanostructured implantable device for local anesthetic delivery
title From micro- to nanostructured implantable device for local anesthetic delivery
title_full From micro- to nanostructured implantable device for local anesthetic delivery
title_fullStr From micro- to nanostructured implantable device for local anesthetic delivery
title_full_unstemmed From micro- to nanostructured implantable device for local anesthetic delivery
title_short From micro- to nanostructured implantable device for local anesthetic delivery
title_sort from micro- to nanostructured implantable device for local anesthetic delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907738/
https://www.ncbi.nlm.nih.gov/pubmed/27354799
http://dx.doi.org/10.2147/IJN.S99028
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