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Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital
INTRODUCTION: Cardiovascular risk factors are prevalent in HIV-positive patients which places them at increased risk for cardiovascular disease (CVD). We aimed to determine the risk factors and risk assessment for CVD in HIV-positive patients with and without antiretroviral therapy. METHODS: This wa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907765/ https://www.ncbi.nlm.nih.gov/pubmed/27347295 http://dx.doi.org/10.11604/pamj.2016.23.206.7041 |
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author | Osegbe, Ifeyinwa Dorothy Soriyan, Oyetunji Olukayode Ogbenna, Abiola Ann Okpara, Henry Chima Azinge, Elaine Chinyere |
author_facet | Osegbe, Ifeyinwa Dorothy Soriyan, Oyetunji Olukayode Ogbenna, Abiola Ann Okpara, Henry Chima Azinge, Elaine Chinyere |
author_sort | Osegbe, Ifeyinwa Dorothy |
collection | PubMed |
description | INTRODUCTION: Cardiovascular risk factors are prevalent in HIV-positive patients which places them at increased risk for cardiovascular disease (CVD). We aimed to determine the risk factors and risk assessment for CVD in HIV-positive patients with and without antiretroviral therapy. METHODS: This was a cross-sectional study of HIV-positive patients attending the Lagos University Teaching Hospital, Nigeria. Anthropometric and blood pressure measurements were performed; fasting lipid profile, plasma glucose, homocysteine and hsCRP were determined, as well as prevalences and risk assessments. Statistical tests were used to compare the groups and p-value <0.05 was considered to be significant. RESULTS: 283 subjects were recruited for this study (100 HIV-positive treatment-naive, 100 HIV-positive treated and 83 HIV negative controls). Compared to the controls, mean (sd) values were significantly higher among HIV-treated subjects: waist circumference = 88.7 (10.4), p = 0.035; systolic bp= 124.9 (20.7), p = 0.014; glucose= 5.54 (1.7), p = 0.015; triglyceride= 2.0 (1.2), p < 0.001; homocysteine= 10.9 (8.9-16.2), p = 0.0003; while hsCRP= 2.9 (1.4-11.6), p = 0.002 and HDL-C = 0.9 (0.4), p = < 0.0001 were higher among the HIV-naïve subjects. Likewise, higher prevalences of the risk factors were noted among the HIV-treated subjects except low HDL-C (p < 0.001) and hsCRP (p = 0.03) which were higher in the HIV-naïve group. Risk assessment using ratios showed high risk for CVD especially in the HIV-naïve group. The median range for Framingham risk assessment was 1.0 - 7.5%. CONCLUSION: Risk factors and risk assessment for CVD are increased in HIV-positive patients with and without antiretroviral therapy. Routine evaluation and risk assessment for CVD irrespective of therapy status is necessary to prevent future cardiovascular events. |
format | Online Article Text |
id | pubmed-4907765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-49077652016-06-24 Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital Osegbe, Ifeyinwa Dorothy Soriyan, Oyetunji Olukayode Ogbenna, Abiola Ann Okpara, Henry Chima Azinge, Elaine Chinyere Pan Afr Med J Research INTRODUCTION: Cardiovascular risk factors are prevalent in HIV-positive patients which places them at increased risk for cardiovascular disease (CVD). We aimed to determine the risk factors and risk assessment for CVD in HIV-positive patients with and without antiretroviral therapy. METHODS: This was a cross-sectional study of HIV-positive patients attending the Lagos University Teaching Hospital, Nigeria. Anthropometric and blood pressure measurements were performed; fasting lipid profile, plasma glucose, homocysteine and hsCRP were determined, as well as prevalences and risk assessments. Statistical tests were used to compare the groups and p-value <0.05 was considered to be significant. RESULTS: 283 subjects were recruited for this study (100 HIV-positive treatment-naive, 100 HIV-positive treated and 83 HIV negative controls). Compared to the controls, mean (sd) values were significantly higher among HIV-treated subjects: waist circumference = 88.7 (10.4), p = 0.035; systolic bp= 124.9 (20.7), p = 0.014; glucose= 5.54 (1.7), p = 0.015; triglyceride= 2.0 (1.2), p < 0.001; homocysteine= 10.9 (8.9-16.2), p = 0.0003; while hsCRP= 2.9 (1.4-11.6), p = 0.002 and HDL-C = 0.9 (0.4), p = < 0.0001 were higher among the HIV-naïve subjects. Likewise, higher prevalences of the risk factors were noted among the HIV-treated subjects except low HDL-C (p < 0.001) and hsCRP (p = 0.03) which were higher in the HIV-naïve group. Risk assessment using ratios showed high risk for CVD especially in the HIV-naïve group. The median range for Framingham risk assessment was 1.0 - 7.5%. CONCLUSION: Risk factors and risk assessment for CVD are increased in HIV-positive patients with and without antiretroviral therapy. Routine evaluation and risk assessment for CVD irrespective of therapy status is necessary to prevent future cardiovascular events. The African Field Epidemiology Network 2016-04-20 /pmc/articles/PMC4907765/ /pubmed/27347295 http://dx.doi.org/10.11604/pamj.2016.23.206.7041 Text en © Ifeyinwa Dorothy Osegbe et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Osegbe, Ifeyinwa Dorothy Soriyan, Oyetunji Olukayode Ogbenna, Abiola Ann Okpara, Henry Chima Azinge, Elaine Chinyere Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital |
title | Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital |
title_full | Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital |
title_fullStr | Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital |
title_full_unstemmed | Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital |
title_short | Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital |
title_sort | risk factors and assessment for cardiovascular disease among hiv-positive patients attending a nigerian tertiary hospital |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907765/ https://www.ncbi.nlm.nih.gov/pubmed/27347295 http://dx.doi.org/10.11604/pamj.2016.23.206.7041 |
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