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Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy
We report a 55-year-old, right-handed patient with intractable left temporal lobe epilepsy, who previously had a partial left temporal lobectomy. The patient could talk during seizures, suggesting that he might have language dominance in the right hemisphere. Presurgical fMRI localization of languag...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907790/ https://www.ncbi.nlm.nih.gov/pubmed/27330987 http://dx.doi.org/10.1016/j.ebcr.2015.10.003 |
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author | Gould, Layla Mickleborough, Marla J.S. Wu, Adam Tellez, Jose Ekstrand, Chelsea Lorentz, Eric Ellchuk, Tasha Babyn, Paul Borowsky, Ron |
author_facet | Gould, Layla Mickleborough, Marla J.S. Wu, Adam Tellez, Jose Ekstrand, Chelsea Lorentz, Eric Ellchuk, Tasha Babyn, Paul Borowsky, Ron |
author_sort | Gould, Layla |
collection | PubMed |
description | We report a 55-year-old, right-handed patient with intractable left temporal lobe epilepsy, who previously had a partial left temporal lobectomy. The patient could talk during seizures, suggesting that he might have language dominance in the right hemisphere. Presurgical fMRI localization of language processing including reading of exception and regular words, pseudohomophones, and dual meaning words confirmed the clinical hypothesis of right language dominance, with only small amounts of activation near the planned surgical resection and, thus, minimal eloquent cortex to avoid during surgery. Postoperatively, the patient was rendered seizure-free without speech deficits. |
format | Online Article Text |
id | pubmed-4907790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-49077902016-06-21 Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy Gould, Layla Mickleborough, Marla J.S. Wu, Adam Tellez, Jose Ekstrand, Chelsea Lorentz, Eric Ellchuk, Tasha Babyn, Paul Borowsky, Ron Epilepsy Behav Case Rep Case Report We report a 55-year-old, right-handed patient with intractable left temporal lobe epilepsy, who previously had a partial left temporal lobectomy. The patient could talk during seizures, suggesting that he might have language dominance in the right hemisphere. Presurgical fMRI localization of language processing including reading of exception and regular words, pseudohomophones, and dual meaning words confirmed the clinical hypothesis of right language dominance, with only small amounts of activation near the planned surgical resection and, thus, minimal eloquent cortex to avoid during surgery. Postoperatively, the patient was rendered seizure-free without speech deficits. Elsevier 2015-12-02 /pmc/articles/PMC4907790/ /pubmed/27330987 http://dx.doi.org/10.1016/j.ebcr.2015.10.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Gould, Layla Mickleborough, Marla J.S. Wu, Adam Tellez, Jose Ekstrand, Chelsea Lorentz, Eric Ellchuk, Tasha Babyn, Paul Borowsky, Ron Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy |
title | Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy |
title_full | Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy |
title_fullStr | Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy |
title_full_unstemmed | Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy |
title_short | Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy |
title_sort | presurgical language mapping in epilepsy: using fmri of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907790/ https://www.ncbi.nlm.nih.gov/pubmed/27330987 http://dx.doi.org/10.1016/j.ebcr.2015.10.003 |
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