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Short-Term Heat Shock Affects Host–Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1

Highly pathogenic avian influenza virus (HPAIV) H5N1 is a highly contagious virus that can cause acute respiratory infections and high human fatality ratio due to excessive inflammatory response. Short-term heat shock, as a stressful condition, could induce the expression of heat shock proteins that...

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Autores principales: Xue, Jia, Fan, Xiaoxu, Yu, Jing, Zhang, Shouping, Xiao, Jin, Hu, Yanxin, Wang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908103/
https://www.ncbi.nlm.nih.gov/pubmed/27379054
http://dx.doi.org/10.3389/fmicb.2016.00924
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author Xue, Jia
Fan, Xiaoxu
Yu, Jing
Zhang, Shouping
Xiao, Jin
Hu, Yanxin
Wang, Ming
author_facet Xue, Jia
Fan, Xiaoxu
Yu, Jing
Zhang, Shouping
Xiao, Jin
Hu, Yanxin
Wang, Ming
author_sort Xue, Jia
collection PubMed
description Highly pathogenic avian influenza virus (HPAIV) H5N1 is a highly contagious virus that can cause acute respiratory infections and high human fatality ratio due to excessive inflammatory response. Short-term heat shock, as a stressful condition, could induce the expression of heat shock proteins that function as molecular chaperones to protect cells against multiple stresses. However, the protective effect of short-term heat shock in influenza infection is far from being understood. In this study, mice were treated at 39°C for 4 h before being infected with HPAIV H5N1. Interestingly, short-term heat shock significantly increased the levels of HSP70 and pro-inflammatory cytokines IL-6, TNF-α, IFN-β, and IFN-γ in the lung tissues of mice. Following HPAIV H5N1 infection, short-term heat shock alleviated immunopathology and viral replication in lung tissue and repressed the weight loss and increased the survival rate of H5N1-infected mice. Our data reported that short-term heat shock provided beneficial anti-HPAIV H5N1 properties in mice model, which offers an alternative strategy for non-drug prevention for influenza infection.
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spelling pubmed-49081032016-07-04 Short-Term Heat Shock Affects Host–Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1 Xue, Jia Fan, Xiaoxu Yu, Jing Zhang, Shouping Xiao, Jin Hu, Yanxin Wang, Ming Front Microbiol Microbiology Highly pathogenic avian influenza virus (HPAIV) H5N1 is a highly contagious virus that can cause acute respiratory infections and high human fatality ratio due to excessive inflammatory response. Short-term heat shock, as a stressful condition, could induce the expression of heat shock proteins that function as molecular chaperones to protect cells against multiple stresses. However, the protective effect of short-term heat shock in influenza infection is far from being understood. In this study, mice were treated at 39°C for 4 h before being infected with HPAIV H5N1. Interestingly, short-term heat shock significantly increased the levels of HSP70 and pro-inflammatory cytokines IL-6, TNF-α, IFN-β, and IFN-γ in the lung tissues of mice. Following HPAIV H5N1 infection, short-term heat shock alleviated immunopathology and viral replication in lung tissue and repressed the weight loss and increased the survival rate of H5N1-infected mice. Our data reported that short-term heat shock provided beneficial anti-HPAIV H5N1 properties in mice model, which offers an alternative strategy for non-drug prevention for influenza infection. Frontiers Media S.A. 2016-06-15 /pmc/articles/PMC4908103/ /pubmed/27379054 http://dx.doi.org/10.3389/fmicb.2016.00924 Text en Copyright © 2016 Xue, Fan, Yu, Zhang, Xiao, Hu and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Xue, Jia
Fan, Xiaoxu
Yu, Jing
Zhang, Shouping
Xiao, Jin
Hu, Yanxin
Wang, Ming
Short-Term Heat Shock Affects Host–Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1
title Short-Term Heat Shock Affects Host–Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1
title_full Short-Term Heat Shock Affects Host–Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1
title_fullStr Short-Term Heat Shock Affects Host–Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1
title_full_unstemmed Short-Term Heat Shock Affects Host–Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1
title_short Short-Term Heat Shock Affects Host–Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1
title_sort short-term heat shock affects host–virus interaction in mice infected with highly pathogenic avian influenza virus h5n1
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908103/
https://www.ncbi.nlm.nih.gov/pubmed/27379054
http://dx.doi.org/10.3389/fmicb.2016.00924
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