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Neuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation

Tissue-type plasminogen activator (t-PA), initially characterized for its critical role in fibrinolysis, also has key functions in both physiologic and pathologic processes in the CNS. Neuroserpin (NSP) is a t-PA specific serine protease inhibitor (serpin) found almost exclusively in the CNS that re...

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Detalles Bibliográficos
Autores principales: Carlson, Karen-Sue B., Nguyen, Lan, Schwartz, Kat, Lawrence, Daniel A., Schwartz, Bradford S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908126/
https://www.ncbi.nlm.nih.gov/pubmed/27378851
http://dx.doi.org/10.3389/fncel.2016.00154