Cargando…

Ex Vivo Apoptosis in CD8+ Lymphocytes Predicts Rectal Cancer Patient Outcome

Background. Apoptotic rates in peripheral blood lymphocytes can predict radiation induced normal tissue toxicity. We studied whether apoptosis in lymphocytes has a prognostic value for therapy outcome. Methods. Lymphocytes of 87 rectal cancer patients were ex vivo irradiated with 2 Gy, 8 Gy, or a co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Winkler, Sebastian, Hoppe, Philipp, Haderlein, Marlen, Hecht, Markus, Fietkau, Rainer, Distel, Luitpold V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908238/ https://www.ncbi.nlm.nih.gov/pubmed/27340400 http://dx.doi.org/10.1155/2016/5076542

Ejemplares similares

The Prognostic Value of FoxP3+ Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+ Cytotoxic T Cell Density
por: Schnellhardt, Sören, et al.
Publicado: (2022)

CD8+ and Regulatory T cells Differentiate Tumor Immune Phenotypes and Predict Survival in Locally Advanced Head and Neck Cancer
por: Echarti, Alessia, et al.
Publicado: (2019)

Is in vivo and ex vivo irradiation equally reliable for individual Radiosensitivity testing by three colour fluorescence in situ hybridization?
por: Mayo, Theresa, et al.
Publicado: (2019)

Spatial distribution of FoxP3+ and CD8+ tumour infiltrating T cells reflects their functional activity
por: Posselt, Rebecca, et al.
Publicado: (2016)

Influence of Gender on Radiosensitivity during Radiochemotherapy of Advanced Rectal Cancer
por: Schuster, Barbara, et al.
Publicado: (2021)

Differences in and Prognostic Value of Quality of Life Data in Rectal Cancer Patients with and without Distant Metastases
por: Frank, Fabian, et al.
Publicado: (2020)

Baseline Quality of Life of Physical Function Is Highly Relevant for Overall Survival in Advanced Rectal Cancer
por: Fitz, Tim, et al.
Publicado: (2022)

Regulatory T cells and cytotoxic T cells close to the epithelial–stromal interface are associated with a favorable prognosis
por: Rudolf, Julian, et al.
Publicado: (2020)

Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells
por: Dobler, Clara, et al.
Publicado: (2020)

Deterioration of Health-Related Quality of Life Scores under Treatment Predicts Longer Survival
por: Jörling, Maike, et al.
Publicado: (2020)

Palbociclib Induces Senescence in Melanoma and Breast Cancer Cells and Leads to Additive Growth Arrest in Combination With Irradiation
por: Jost, Tina, et al.
Publicado: (2021)

Dual mTOR/DNA-PK Inhibitor CC-115 Induces Cell Death in Melanoma Cells and Has Radiosensitizing Potential
por: Bürkel, Felix, et al.
Publicado: (2020)

Increase in non-professional phagocytosis during the progression of cell cycle
por: Hofmann, Alexander, et al.
Publicado: (2021)

PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation
por: Jonuscheit, Stephanie, et al.
Publicado: (2021)

Cell-in-cell structures are more potent predictors of outcome than senescence or apoptosis in head and neck squamous cell carcinomas
por: Schenker, Hannah, et al.
Publicado: (2017)

Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation
por: Gottwald, Dorian, et al.
Publicado: (2020)

PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts
por: Weigert, Verena, et al.
Publicado: (2020)

Kinase inhibitors increase individual radiation sensitivity in normal cells of cancer patients
por: Jost, Tina, et al.
Publicado: (2022)

Salivary gland carcinoma (SGC) with perineural spread and/or positive resection margin – high locoregional control rates after photon (chemo) radiotherapy - experience from a monocentric analysis
por: Haderlein, Marlen, et al.
Publicado: (2019)

Cell-in-cell phenomenon: leukocyte engulfment by non-tumorigenic cells and cancer cell lines
por: Bauer, Mareike F., et al.
Publicado: (2021)

Influence of alectinib and crizotinib on ionizing radiation - in vitro analysis of ALK/ROS1-wildtype lung tissue cells
por: Jost, Tina, et al.
Publicado: (2022)

Impact of COVID-19 on Quality of Life in Long-Term Advanced Rectal Cancer Survivors
por: Blasko, Daniel, et al.
Publicado: (2023)

Targeted Therapy, Chemotherapy, Immunotherapy and Novel Treatment Options for Different Subtypes of Salivary Gland Cancer
por: Mueller, Sarina K., et al.
Publicado: (2022)

Ex vivo radiosensitivity is increased in non-cancer patients taking valproate
por: Stritzelberger, Jenny, et al.
Publicado: (2020)

Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients
por: Schuster, Barbara, et al.
Publicado: (2018)

Benchmarking ChatGPT-4 on a radiation oncology in-training exam and Red Journal Gray Zone cases: potentials and challenges for ai-assisted medical education and decision making in radiation oncology
por: Huang, Yixing, et al.
Publicado: (2023)

Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells
por: Faulhaber, Eva-Maria, et al.
Publicado: (2021)

Substantial Impairment of Quality of Life during COVID-19 Pandemic in Patients with Advanced Rectal Cancer
por: Dennison, Irene, et al.
Publicado: (2022)

Efavirenz Has the Highest Anti-Proliferative Effect of Non-Nucleoside Reverse Transcriptase Inhibitors against Pancreatic Cancer Cells
por: Hecht, Markus, et al.
Publicado: (2015)

Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial
por: Haderlein, Marlen, et al.
Publicado: (2020)

Distinct increased outliers among 136 rectal cancer patients assessed by γH2AX
por: Kroeber, Jana, et al.
Publicado: (2015)

High-grade salivary gland cancer: is surgery followed by radiotherapy an adequate treatment to reach tumor control? Results from a tertiary referral centre focussing on incidence and management of distant metastases
por: Freitag, Viola, et al.
Publicado: (2021)

Prospective Evaluation of All-lesion Versus Single-lesion Radiotherapy in Combination With PD-1/PD-L1 Immune Checkpoint Inhibitors
por: Schubert, Philipp, et al.
Publicado: (2020)

The Effect of Xevinapant Combined with Ionizing Radiation on HNSCC and Normal Tissue Cells and the Impact of Xevinapant on Its Targeted Proteins cIAP1 and XIAP
por: Fleischmann, Julia, et al.
Publicado: (2023)

Cytotoxic effect of Efavirenz in BxPC-3 pancreatic cancer cells is based on oxidative stress and is synergistic with ionizing radiation
por: Hecht, Markus, et al.
Publicado: (2018)

Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts
por: Scheper, Julian, et al.
Publicado: (2022)

In Vitro Analysis of Superparamagnetic Iron Oxide Nanoparticles Coated with APTES as Possible Radiosensitizers for HNSCC Cells
por: Emer, Clara, et al.
Publicado: (2023)

Oligometastatic head and neck cancer: Which patients benefit from radical local treatment of all tumour sites?
por: Weissmann, Thomas, et al.
Publicado: (2021)

Individual radiosensitivity in a breast cancer collective is changed with the patients’ age
por: Auer, Judith, et al.
Publicado: (2014)

Ex Vivo Chromosomal Radiosensitivity Testing in Patients with Pathological Germline Variants in Breast Cancer High-Susceptibility Genes BReast CAncer 1 and BReast CAncer 2
por: Zuhair Kassem, Tara, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j45cad4q60oe8333evmga6v08e