Cargando…

Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction

Background. DKK1 antagonizes canonical Wnt signalling through high-affinity binding to LRP5/6, an essential component of the Wnt receptor complex responsible for mediating downstream canonical Wnt signalling. DKK1 overexpression is known for its pathological implications in osteoporosis, cancer, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iozzi, Sara, Remelli, Rosaria, Lelli, Barbara, Diamanti, Daniela, Pileri, Silvia, Bracci, Luisa, Roncarati, Renza, Caricasole, Andrea, Bernocco, Simonetta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scholarly Research Network 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908242/ https://www.ncbi.nlm.nih.gov/pubmed/27398238 http://dx.doi.org/10.5402/2012/823875

Ejemplares similares

A Novel Inhibitor of DKK1/LRP6 Interactions Against the Alzheimer Disease: An Insilco Approach
por: Prajapat, Manisha, et al.
Publicado: (2023)

SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease
por: Mason, James J., et al.
Publicado: (2010)

Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation
por: Li, Yonghe, et al.
Publicado: (2010)

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells
por: Massai, Luisa, et al.
Publicado: (2013)

Drug Discovery of DKK1 Inhibitors
por: Jiang, Hewen, et al.
Publicado: (2022)

Dkk1: A key molecule in joint remodelling and fibrosis
por: Klavdianou, Kalliopi, et al.
Publicado: (2017)

More severe phenotype of early‐onset osteoporosis associated with recessive form of LRP5 and combination with DKK1 or WNT3A
por: Caetano da Silva, Caroline, et al.
Publicado: (2021)

Distinct roles of DKK1 and DKK2 in tumor angiogenesis
por: Park, Hongryeol, et al.
Publicado: (2013)

A Novel Phage-Library-Selected Peptide Inhibits Human TNF-α Binding to Its Receptors
por: Brunetti, Jlenia, et al.
Publicado: (2014)

Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model
por: Park, Bo Mi, et al.
Publicado: (2017)

ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway
por: Zeng, Peng, et al.
Publicado: (2021)

Clinical relevance of genetic polymorphisms in WNT signaling pathway (SFRP1, WNT3A, CTNNB1, WIF-1, DKK-1, LRP5, LRP6) on pulmonary tuberculosis in a Chinese population
por: Huang, Qian, et al.
Publicado: (2022)

Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins
por: Patel, Saleha, et al.
Publicado: (2018)

Engineering potent long-acting variants of the Wnt inhibitor DKK2
por: Sopko, Richelle, et al.
Publicado: (2017)

Epigenetic Silencing of DKK3 in Medulloblastoma
por: Valdora, Francesca, et al.
Publicado: (2013)

BAC-Dkk3-EGFP Transgenic Mouse: An In Vivo Analytical Tool for Dkk3 Expression
por: Muranishi, Yuki, et al.
Publicado: (2012)

Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene
por: Gaviraghi, Margherita, et al.
Publicado: (2008)

Wnt Pathway Inhibitor DKK1: A Potential Novel Biomarker for Adiposity
por: Ali, Hira, et al.
Publicado: (2019)

COMBINING SCLEROSTIN AND DKK1 INHIBITORS TO IMPROVE BONE PROPERTIES IN THE AGED SKELETON
por: Choi, Roy, et al.
Publicado: (2022)

Methylation Assessment of Two DKK2 and DKK4 Genes in Oral Squamous Cell Carcinoma Patients
por: KHEIRANDISH, Sedigheh, et al.
Publicado: (2020)

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
por: Ren, Qian, et al.
Publicado: (2021)

Methylation Patterns of DKK1, DKK3 and GSK3β Are Accompanied with Different Expression Levels in Human Astrocytoma
por: Kafka, Anja, et al.
Publicado: (2021)

Role of DKK4 in Tumorigenesis and Tumor Progression
por: Cai, Xinjia, et al.
Publicado: (2018)

The role of Sfrp and DKK proteins in cardiomyocyte development
por: Hsueh, Ying‐Chang, et al.
Publicado: (2021)

The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis
por: Guo, Yanchun, et al.
Publicado: (2019)

Role of Wnt-signaling inhibitors DKK-1 and sclerostin in bone fragility associated with Turner syndrome
por: Chiarito, M., et al.
Publicado: (2022)

DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti‐DKK1 therapeutic DKN‐01
por: Jarman, Edward J., et al.
Publicado: (2022)

Baculovirus Actin Rearrangement-Inducing Factor 1 Can Remodel the Mammalian Actin Cytoskeleton
por: Steffen, Anika, et al.
Publicado: (2023)

Dissecting Molecular Differences between Wnt Coreceptors LRP5 and LRP6
por: MacDonald, Bryan T., et al.
Publicado: (2011)

Low density lipoprotein receptors LRP-1 and LRP-2 in C. elegans
por: Minor, Paul J, et al.
Publicado: (2019)

Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma
por: Dun, Xiaoyi, et al.
Publicado: (2010)

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters
por: Kiefer, Alexander F., et al.
Publicado: (2022)

DKK1 as a novel target for myeloma immunotherapy
por: Qian, Jianfei, et al.
Publicado: (2012)

DKK-1 in prostate cancer diagnosis and follow up
por: D’Amelio, Patrizia, et al.
Publicado: (2014)

Molecular Evolution and Protein Structure Variation of Dkk Family
por: Wen, Binhong, et al.
Publicado: (2023)

Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone
por: Williams, Bart O, et al.
Publicado: (2009)

KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae
por: Kanai, Yoshimitsu, et al.
Publicado: (2014)

Anti-LRP2 Nephropathy
por: Gallan, Alexander J., et al.
Publicado: (2020)

Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition
por: Riddle, Ryan C., et al.
Publicado: (2013)

sLRP1ng Up Glucose: LRP1 Regulates Hepatic Insulin Responses
por: Lee, Stephen D., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dppbjef3757dd2vpmf3ns8g7fv