Cargando…

CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis

Adipose tissue lipolysis produces glycerol and nonesterified fatty acids (NEFA) that serve as energy sources during nutrient scarcity. Adipose tissue lipolysis is tightly regulated and excessive lipolysis causes hepatic steatosis, as NEFA released from adipose tissue constitutes a major source of TG...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jong-Gil, Xu, Xu, Cho, Sungyun, Hur, Kyu Yeon, Lee, Myung-Shik, Kersten, Sander, Lee, Ann-Hwee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908383/ https://www.ncbi.nlm.nih.gov/pubmed/27301791 http://dx.doi.org/10.1038/srep27938

Ejemplares similares

Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice
por: Krumm, Christopher S., et al.
Publicado: (2021)

Hepatic PTP4A1 ameliorates high-fat diet-induced hepatosteatosis and hyperglycemia by the activation of the CREBH/FGF21 axis
por: Hwang, Byungtae, et al.
Publicado: (2023)

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms
por: Satoh, Aoi, et al.
Publicado: (2020)

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases
por: Kim, Kook Hwan, et al.
Publicado: (2014)

FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice
por: Zhao, Cuiqing, et al.
Publicado: (2015)

Suppressive Effect of Autocrine FGF21 on Autophagy-Deficient Hepatic Tumorigenesis
por: Kim, Jinyoung, et al.
Publicado: (2022)

CREBH Regulates Systemic Glucose and Lipid Metabolism
por: Nakagawa, Yoshimi, et al.
Publicado: (2018)

Sympathetic overdrive and unrestrained adipose lipolysis drive alcohol-induced hepatic steatosis in rodents
por: Zhou, Chunxue, et al.
Publicado: (2023)

CREBH Determines the Severity of Sulpyrine-Induced Fatal Shock
por: Kamiyama, Naganori, et al.
Publicado: (2013)

CREBH Couples Circadian Clock With Hepatic Lipid Metabolism
por: Zheng, Ze, et al.
Publicado: (2016)

FGF21 regulates hepatic metabolic pathways to improve steatosis and inflammation
por: Keinicke, Helle, et al.
Publicado: (2020)

Hypoxia-Induced Adipose Lipolysis Requires Fibroblast Growth Factor 21
por: Wu, Guicheng, et al.
Publicado: (2020)

SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice
por: Lee, Bonggi, et al.
Publicado: (2022)

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
por: Villarroya, Joan, et al.
Publicado: (2018)

Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans
por: Kim, Kook Hwan, et al.
Publicado: (2013)

Alleviation of Hepatic Steatosis by Alpha-Defensin Is Associated with Enhanced Lipolysis
por: Maraga, Emad, et al.
Publicado: (2023)

Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid: Relationship With Plasma FGF21 and Body Adiposity
por: Tan, Bee K., et al.
Publicado: (2011)

CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions
por: Nakagawa, Yoshimi, et al.
Publicado: (2021)

CREBH regulation of lipid metabolism through multifaceted functions that improve arteriosclerosis
por: Nakagawa, Yoshimi, et al.
Publicado: (2022)

Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis
por: Hsiao, Pi-Jung, et al.
Publicado: (2017)

Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα
por: Ruppert, Philip M. M., et al.
Publicado: (2019)

The Molecular Brakes of Adipose Tissue Lipolysis
por: Li, Yongguo, et al.
Publicado: (2022)

E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9
por: Rodrigues, Robim M., et al.
Publicado: (2021)

Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis
por: Liu, Liming, et al.
Publicado: (2017)

Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts
por: Sunaga, Hiroaki, et al.
Publicado: (2019)

FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice
por: Véniant, Murielle M., et al.
Publicado: (2012)

Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake
por: Cedó, Lídia, et al.
Publicado: (2017)

CrebH protects against liver injury associated with colonic inflammation via modulation of exosomal miRNA
por: Lee, Sang-Hee, et al.
Publicado: (2023)

FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis
por: Li, Haifang, et al.
Publicado: (2021)

miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction
por: Hu, Ying, et al.
Publicado: (2020)

GPCR in Adipose Tissue Function—Focus on Lipolysis
por: Malfacini, Davide, et al.
Publicado: (2023)

Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)
por: Zhang, Ke, et al.
Publicado: (2023)

ASC Regulates Subcutaneous Adipose Tissue Lipogenesis and Lipolysis via p53/AMPKα Axis
por: Chen, Hong, et al.
Publicado: (2022)

Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH
por: Chanda, Dipanjan, et al.
Publicado: (2013)

Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue
por: Park, Sujeong, et al.
Publicado: (2021)

Effects of FGF21‐secreting adipose‐derived stem cells in thioacetamide‐induced hepatic fibrosis
por: Kang, Hwansu, et al.
Publicado: (2018)

Endoplasmic reticulum stress in adipose tissue augments lipolysis
por: Bogdanovic, Elena, et al.
Publicado: (2015)

Periparturient lipolysis and oxylipid biosynthesis in bovine adipose tissues
por: Contreras, G. Andres, et al.
Publicado: (2017)

Protocol for assessing exvivo lipolysis of murine adipose tissue
por: Roy, Debasish, et al.
Publicado: (2022)

FGF19 subfamily members: FGF19 and FGF21
por: Dolegowska, Katarzyna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_d2dkqogd9obcmujippb4vccs6b