Cargando…

Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols

The title compounds, C(22)H(29)NO(2) (3) and C(22)H(29)NO(2) (4) [systematic names: (1S*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol and (1R*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol, are diastereomers with the re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tewes, Bastian, Frehland, Bastian, Fröhlich, Roland, Wünsch, Bernhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2016
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908524/ https://www.ncbi.nlm.nih.gov/pubmed/27308019 http://dx.doi.org/10.1107/S2056989016005843

Ejemplares similares

Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists
por: Tewes, Bastian, et al.
Publicado: (2016)

3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one at 125 K
por: Cheng, Xiang-Wei
Publicado: (2008)

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity
por: Shipton, Olivia A., et al.
Publicado: (2014)

GluN2A and GluN2B NMDA receptors use distinct allosteric routes
por: Tian, Meilin, et al.
Publicado: (2021)

Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors
por: Karakas, Erkan, et al.
Publicado: (2011)

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors
por: Schreiber, Julian A., et al.
Publicado: (2019)

Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists
por: Rouzbeh, Nirvan, et al.
Publicado: (2023)

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors
por: Chopra, Divyan A., et al.
Publicado: (2017)

The Nucleosome Assembly Protein TSPYL2 Regulates the Expression of NMDA Receptor Subunits GluN2A and GluN2B
por: Tsang, Ka Hing, et al.
Publicado: (2014)

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
por: Grand, Teddy, et al.
Publicado: (2018)

Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands ((11)C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors
por: Cai, Lisheng, et al.
Publicado: (2023)

4-Acetyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine
por: Zhao, Qing-Jie, et al.
Publicado: (2008)

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening
por: Talukder, Iehab, et al.
Publicado: (2011)

GluN1 and GluN2A NMDA Receptor Subunits Increase in the Hippocampus during Memory Consolidation in the Rat
por: Cercato, Magali C., et al.
Publicado: (2017)

Influence of GluN2 subunit identity on NMDA receptor function
por: Wyllie, D.J.A., et al.
Publicado: (2013)

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences
por: McKay, Sean, et al.
Publicado: (2018)

Mg(2+) block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones
por: Huang, Zhuo, et al.
Publicado: (2014)

Endocytosis of GluN2B-containing NMDA receptor mediates NMDA-induced excitotoxicity
por: Wu, Yu, et al.
Publicado: (2017)

[2.2]Paracyclophane‐Based TCN‐201 Analogs as GluN2A‐Selective NMDA Receptor Antagonists
por: Rajan, Remya, et al.
Publicado: (2021)

Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors
por: Yakovlev, Aleksey V., et al.
Publicado: (2017)

Astrocytes increase the activity of synaptic GluN2B NMDA receptors
por: Hahn, Junghyun, et al.
Publicado: (2015)

Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia
por: Vinnakota, Chitra, et al.
Publicado: (2023)

Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors
por: Zeng, Yue, et al.
Publicado: (2022)

Palmitoylation at Two Cysteine Clusters on the C-Terminus of GluN2A and GluN2B Differentially Control Synaptic Targeting of NMDA Receptors
por: Mattison, Hayley A., et al.
Publicado: (2012)

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis
por: Üner, Aykut, et al.
Publicado: (2015)

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes
por: Shelkar, Gajanan P., et al.
Publicado: (2019)

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives
por: Ritter, Nadine, et al.
Publicado: (2023)

An Alternating GluN1-2-1-2 Subunit Arrangement in Mature NMDA Receptors
por: Riou, Morgane, et al.
Publicado: (2012)

The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures
por: Smaga, Irena, et al.
Publicado: (2021)

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients
por: Mellone, Manuela, et al.
Publicado: (2015)

GluN2 Subunit-Dependent Redox Modulation of NMDA Receptor Activation by Homocysteine
por: Sibarov, Dmitry A., et al.
Publicado: (2020)

4-Methyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-5-carbaldehyde
por: Ravichandran, K., et al.
Publicado: (2009)

Targeted NMDA Receptor Interventions for Autism: Developmentally Determined Expression of GluN2B and GluN2A-Containing Receptors and Balanced Allosteric Modulatory Approaches
por: Deutsch, Stephen I., et al.
Publicado: (2022)

GluN2A‐Selective NMDA Receptor Antagonists: Mimicking the U‐Shaped Bioactive Conformation of TCN‐201 by a [2.2]Paracyclophane System
por: Steigerwald, Ruben, et al.
Publicado: (2022)

5-Chloroacetyl-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one
por: Ravichandran, K., et al.
Publicado: (2009)

GluN2A Subunit-Containing NMDA Receptors Are the Preferential Neuronal Targets of Homocysteine
por: Sibarov, Dmitry A., et al.
Publicado: (2016)

Functional assessment of the NMDA receptor variant GluN2A (R586K)
por: Marwick, Katie F.M., et al.
Publicado: (2017)

GluN2D NMDA Receptors Gate Fear Extinction Learning and Interneuron Plasticity
por: Dubois, Christophe J., et al.
Publicado: (2021)

2-Ethoxymethyl-6-ethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione
por: El-Brollosy, Nasser R., et al.
Publicado: (2012)

3,3,4,4-Tetrafluoro-2,3,4,5-tetrahydro-1,6-benzodioxocine-8-carbaldehyde
por: Zeng, Zhuo, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_h3o35gb55aq9ijuk1tob2vk9j2