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Selection and Biosensor Application of Aptamers for Small Molecules
Small molecules play a major role in the human body and as drugs, toxins, and chemicals. Tools to detect and quantify them are therefore in high demand. This review will give an overview about aptamers interacting with small molecules and their selection. We discuss the current state of the field, i...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908669/ https://www.ncbi.nlm.nih.gov/pubmed/27379229 http://dx.doi.org/10.3389/fchem.2016.00025 |
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author | Pfeiffer, Franziska Mayer, Günter |
author_facet | Pfeiffer, Franziska Mayer, Günter |
author_sort | Pfeiffer, Franziska |
collection | PubMed |
description | Small molecules play a major role in the human body and as drugs, toxins, and chemicals. Tools to detect and quantify them are therefore in high demand. This review will give an overview about aptamers interacting with small molecules and their selection. We discuss the current state of the field, including advantages as well as problems associated with their use and possible solutions to tackle these. We then discuss different kinds of small molecule aptamer-based sensors described in literature and their applications, ranging from detecting drinking water contaminations to RNA imaging. |
format | Online Article Text |
id | pubmed-4908669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49086692016-07-04 Selection and Biosensor Application of Aptamers for Small Molecules Pfeiffer, Franziska Mayer, Günter Front Chem Chemistry Small molecules play a major role in the human body and as drugs, toxins, and chemicals. Tools to detect and quantify them are therefore in high demand. This review will give an overview about aptamers interacting with small molecules and their selection. We discuss the current state of the field, including advantages as well as problems associated with their use and possible solutions to tackle these. We then discuss different kinds of small molecule aptamer-based sensors described in literature and their applications, ranging from detecting drinking water contaminations to RNA imaging. Frontiers Media S.A. 2016-06-15 /pmc/articles/PMC4908669/ /pubmed/27379229 http://dx.doi.org/10.3389/fchem.2016.00025 Text en Copyright © 2016 Pfeiffer and Mayer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Pfeiffer, Franziska Mayer, Günter Selection and Biosensor Application of Aptamers for Small Molecules |
title | Selection and Biosensor Application of Aptamers for Small Molecules |
title_full | Selection and Biosensor Application of Aptamers for Small Molecules |
title_fullStr | Selection and Biosensor Application of Aptamers for Small Molecules |
title_full_unstemmed | Selection and Biosensor Application of Aptamers for Small Molecules |
title_short | Selection and Biosensor Application of Aptamers for Small Molecules |
title_sort | selection and biosensor application of aptamers for small molecules |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908669/ https://www.ncbi.nlm.nih.gov/pubmed/27379229 http://dx.doi.org/10.3389/fchem.2016.00025 |
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