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Directions for new developments on statistical design and analysis of small population group trials
BACKGROUND: Most statistical design and analysis methods for clinical trials have been developed and evaluated where at least several hundreds of patients could be recruited. These methods may not be suitable to evaluate therapies if the sample size is unavoidably small, which is usually termed by s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908723/ https://www.ncbi.nlm.nih.gov/pubmed/27301273 http://dx.doi.org/10.1186/s13023-016-0464-5 |