Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate

AIM: To assess the long-term effectiveness of hepatitis B virus vaccine and the need for a booster dose among children who received three doses of vaccine during infancy in Red Sea Governorate. METHODS: A cross-sectional study was performed. Interviews with children (9 months to 16 years) and parent...

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Autores principales: Sami, Samia M., Salama, Iman I., Abdel-Latif, Ghada A., El Etreby, Lobna A., Metwally, Ahmed I., Abd El haliem, Naglaa F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institute of Immunobiology and Human Genetics 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908735/
https://www.ncbi.nlm.nih.gov/pubmed/27335590
http://dx.doi.org/10.3889/oamjms.2016.043
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author Sami, Samia M.
Salama, Iman I.
Abdel-Latif, Ghada A.
El Etreby, Lobna A.
Metwally, Ahmed I.
Abd El haliem, Naglaa F.
author_facet Sami, Samia M.
Salama, Iman I.
Abdel-Latif, Ghada A.
El Etreby, Lobna A.
Metwally, Ahmed I.
Abd El haliem, Naglaa F.
author_sort Sami, Samia M.
collection PubMed
description AIM: To assess the long-term effectiveness of hepatitis B virus vaccine and the need for a booster dose among children who received three doses of vaccine during infancy in Red Sea Governorate. METHODS: A cross-sectional study was performed. Interviews with children (9 months to 16 years) and parents were done. Blood samples to assess Hepatitis B markers were tested. Children showing no seroprotection received a booster dose to assess their anamnestic response after four weeks and one year later. RESULTS: None of the participants had evidence of chronic Hepatitis B. The seroprotection rate was 23.3% and it significantly decreased with age. Multivariate logistic analysis revealed that older age was the significant predicting variable for having no seroprotective level, while baseline anti-HBs level < 3.3 IU/L was the predicting variable for not developing early anamnestic response or loss of late anamnestic response. CONCLUSION: Long-term immunity persists among children who received complete series of hepatitis B vaccination during infancy even in absence or reduction of anti-HBs over time. Therefore, a booster dose is not necessary to maintain immunity till the age of sixteen.
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spelling pubmed-49087352016-06-22 Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate Sami, Samia M. Salama, Iman I. Abdel-Latif, Ghada A. El Etreby, Lobna A. Metwally, Ahmed I. Abd El haliem, Naglaa F. Open Access Maced J Med Sci Basic Science AIM: To assess the long-term effectiveness of hepatitis B virus vaccine and the need for a booster dose among children who received three doses of vaccine during infancy in Red Sea Governorate. METHODS: A cross-sectional study was performed. Interviews with children (9 months to 16 years) and parents were done. Blood samples to assess Hepatitis B markers were tested. Children showing no seroprotection received a booster dose to assess their anamnestic response after four weeks and one year later. RESULTS: None of the participants had evidence of chronic Hepatitis B. The seroprotection rate was 23.3% and it significantly decreased with age. Multivariate logistic analysis revealed that older age was the significant predicting variable for having no seroprotective level, while baseline anti-HBs level < 3.3 IU/L was the predicting variable for not developing early anamnestic response or loss of late anamnestic response. CONCLUSION: Long-term immunity persists among children who received complete series of hepatitis B vaccination during infancy even in absence or reduction of anti-HBs over time. Therefore, a booster dose is not necessary to maintain immunity till the age of sixteen. Institute of Immunobiology and Human Genetics 2016-06-15 2016-05-24 /pmc/articles/PMC4908735/ /pubmed/27335590 http://dx.doi.org/10.3889/oamjms.2016.043 Text en Copyright: © 2016 Samia M. Sami, Iman I. Salama, Ghada A. Abdel-Latif, Lobna A. El Etreby, Ahmed I. Metwally, Naglaa F. Abd El haliem. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Basic Science
Sami, Samia M.
Salama, Iman I.
Abdel-Latif, Ghada A.
El Etreby, Lobna A.
Metwally, Ahmed I.
Abd El haliem, Naglaa F.
Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate
title Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate
title_full Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate
title_fullStr Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate
title_full_unstemmed Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate
title_short Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate
title_sort hepatitis b seroprotection and the response to a challenging dose among vaccinated children in red sea governorate
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908735/
https://www.ncbi.nlm.nih.gov/pubmed/27335590
http://dx.doi.org/10.3889/oamjms.2016.043
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