Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate
AIM: To assess the long-term effectiveness of hepatitis B virus vaccine and the need for a booster dose among children who received three doses of vaccine during infancy in Red Sea Governorate. METHODS: A cross-sectional study was performed. Interviews with children (9 months to 16 years) and parent...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Institute of Immunobiology and Human Genetics
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908735/ https://www.ncbi.nlm.nih.gov/pubmed/27335590 http://dx.doi.org/10.3889/oamjms.2016.043 |
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author | Sami, Samia M. Salama, Iman I. Abdel-Latif, Ghada A. El Etreby, Lobna A. Metwally, Ahmed I. Abd El haliem, Naglaa F. |
author_facet | Sami, Samia M. Salama, Iman I. Abdel-Latif, Ghada A. El Etreby, Lobna A. Metwally, Ahmed I. Abd El haliem, Naglaa F. |
author_sort | Sami, Samia M. |
collection | PubMed |
description | AIM: To assess the long-term effectiveness of hepatitis B virus vaccine and the need for a booster dose among children who received three doses of vaccine during infancy in Red Sea Governorate. METHODS: A cross-sectional study was performed. Interviews with children (9 months to 16 years) and parents were done. Blood samples to assess Hepatitis B markers were tested. Children showing no seroprotection received a booster dose to assess their anamnestic response after four weeks and one year later. RESULTS: None of the participants had evidence of chronic Hepatitis B. The seroprotection rate was 23.3% and it significantly decreased with age. Multivariate logistic analysis revealed that older age was the significant predicting variable for having no seroprotective level, while baseline anti-HBs level < 3.3 IU/L was the predicting variable for not developing early anamnestic response or loss of late anamnestic response. CONCLUSION: Long-term immunity persists among children who received complete series of hepatitis B vaccination during infancy even in absence or reduction of anti-HBs over time. Therefore, a booster dose is not necessary to maintain immunity till the age of sixteen. |
format | Online Article Text |
id | pubmed-4908735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Institute of Immunobiology and Human Genetics |
record_format | MEDLINE/PubMed |
spelling | pubmed-49087352016-06-22 Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate Sami, Samia M. Salama, Iman I. Abdel-Latif, Ghada A. El Etreby, Lobna A. Metwally, Ahmed I. Abd El haliem, Naglaa F. Open Access Maced J Med Sci Basic Science AIM: To assess the long-term effectiveness of hepatitis B virus vaccine and the need for a booster dose among children who received three doses of vaccine during infancy in Red Sea Governorate. METHODS: A cross-sectional study was performed. Interviews with children (9 months to 16 years) and parents were done. Blood samples to assess Hepatitis B markers were tested. Children showing no seroprotection received a booster dose to assess their anamnestic response after four weeks and one year later. RESULTS: None of the participants had evidence of chronic Hepatitis B. The seroprotection rate was 23.3% and it significantly decreased with age. Multivariate logistic analysis revealed that older age was the significant predicting variable for having no seroprotective level, while baseline anti-HBs level < 3.3 IU/L was the predicting variable for not developing early anamnestic response or loss of late anamnestic response. CONCLUSION: Long-term immunity persists among children who received complete series of hepatitis B vaccination during infancy even in absence or reduction of anti-HBs over time. Therefore, a booster dose is not necessary to maintain immunity till the age of sixteen. Institute of Immunobiology and Human Genetics 2016-06-15 2016-05-24 /pmc/articles/PMC4908735/ /pubmed/27335590 http://dx.doi.org/10.3889/oamjms.2016.043 Text en Copyright: © 2016 Samia M. Sami, Iman I. Salama, Ghada A. Abdel-Latif, Lobna A. El Etreby, Ahmed I. Metwally, Naglaa F. Abd El haliem. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Basic Science Sami, Samia M. Salama, Iman I. Abdel-Latif, Ghada A. El Etreby, Lobna A. Metwally, Ahmed I. Abd El haliem, Naglaa F. Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate |
title | Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate |
title_full | Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate |
title_fullStr | Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate |
title_full_unstemmed | Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate |
title_short | Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate |
title_sort | hepatitis b seroprotection and the response to a challenging dose among vaccinated children in red sea governorate |
topic | Basic Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908735/ https://www.ncbi.nlm.nih.gov/pubmed/27335590 http://dx.doi.org/10.3889/oamjms.2016.043 |
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