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Hypercalcemia as a Cause of Kidney Failure: Case Report
BACKGROUND: Hypercalcemia is a common manifestation in clinical practice and occurs as a result of primary hyperparathyroidism, malignancy, milk-alkali syndrome, hyper or hypothyroidism, sarcoidosis and other known and unknown causes. Patients with milk-alkali syndrome typically are presented with r...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Institute of Immunobiology and Human Genetics
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908746/ https://www.ncbi.nlm.nih.gov/pubmed/27335601 http://dx.doi.org/10.3889/oamjms.2016.044 |
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author | Stojceva-Taneva, Olivera Taneva, Borjanka Selim, Gjulsen |
author_facet | Stojceva-Taneva, Olivera Taneva, Borjanka Selim, Gjulsen |
author_sort | Stojceva-Taneva, Olivera |
collection | PubMed |
description | BACKGROUND: Hypercalcemia is a common manifestation in clinical practice and occurs as a result of primary hyperparathyroidism, malignancy, milk-alkali syndrome, hyper or hypothyroidism, sarcoidosis and other known and unknown causes. Patients with milk-alkali syndrome typically are presented with renal failure, hypercalcemia, and metabolic alkalosis caused by the ingestion of calcium and absorbable alkali. This syndrome is caused by high intake of milk and sodium bicarbonate. CASE PRESENTATION: We present a 28-year old male admitted to hospital with a one-month history of nausea, vomiting, epigastric pain, increased blood pressure and worsening of renal function with hypercalcemia. His serum PTH level was almost undetectable; he had mild alkalosis, renal failure with eGFR of 42 ml/min, anemia, hypertension and abnormal ECG with shortened QT interval and ST elevation in V1-V4. He had a positive medical history for calcium-containing antacids intake and after ruling out primary hyperparathyroidism, malignancy, multiple myelomas, sarcoidosis, and thyroid dysfunction, it seemed plausible to diagnose him as having the milk-alkali syndrome. CONCLUSION: Although milk-alkali syndrome currently may be more probably a result of calcium and vitamin D intake in postmenopausal women, or in elderly men with reduced kidney function taking calcium-containing medications, one should not exclude the possibility of its appearance in younger patients taking calcium-containing medications and consider it a serious condition taking into account its possibility of inducing renal insufficiency. |
format | Online Article Text |
id | pubmed-4908746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Institute of Immunobiology and Human Genetics |
record_format | MEDLINE/PubMed |
spelling | pubmed-49087462016-06-22 Hypercalcemia as a Cause of Kidney Failure: Case Report Stojceva-Taneva, Olivera Taneva, Borjanka Selim, Gjulsen Open Access Maced J Med Sci Case Report BACKGROUND: Hypercalcemia is a common manifestation in clinical practice and occurs as a result of primary hyperparathyroidism, malignancy, milk-alkali syndrome, hyper or hypothyroidism, sarcoidosis and other known and unknown causes. Patients with milk-alkali syndrome typically are presented with renal failure, hypercalcemia, and metabolic alkalosis caused by the ingestion of calcium and absorbable alkali. This syndrome is caused by high intake of milk and sodium bicarbonate. CASE PRESENTATION: We present a 28-year old male admitted to hospital with a one-month history of nausea, vomiting, epigastric pain, increased blood pressure and worsening of renal function with hypercalcemia. His serum PTH level was almost undetectable; he had mild alkalosis, renal failure with eGFR of 42 ml/min, anemia, hypertension and abnormal ECG with shortened QT interval and ST elevation in V1-V4. He had a positive medical history for calcium-containing antacids intake and after ruling out primary hyperparathyroidism, malignancy, multiple myelomas, sarcoidosis, and thyroid dysfunction, it seemed plausible to diagnose him as having the milk-alkali syndrome. CONCLUSION: Although milk-alkali syndrome currently may be more probably a result of calcium and vitamin D intake in postmenopausal women, or in elderly men with reduced kidney function taking calcium-containing medications, one should not exclude the possibility of its appearance in younger patients taking calcium-containing medications and consider it a serious condition taking into account its possibility of inducing renal insufficiency. Institute of Immunobiology and Human Genetics 2016-06-15 2016-03-18 /pmc/articles/PMC4908746/ /pubmed/27335601 http://dx.doi.org/10.3889/oamjms.2016.044 Text en Copyright: © 2016 Olivera Stojceva-Taneva, Borjanka Taneva, Gjulsen Selim. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Case Report Stojceva-Taneva, Olivera Taneva, Borjanka Selim, Gjulsen Hypercalcemia as a Cause of Kidney Failure: Case Report |
title | Hypercalcemia as a Cause of Kidney Failure: Case Report |
title_full | Hypercalcemia as a Cause of Kidney Failure: Case Report |
title_fullStr | Hypercalcemia as a Cause of Kidney Failure: Case Report |
title_full_unstemmed | Hypercalcemia as a Cause of Kidney Failure: Case Report |
title_short | Hypercalcemia as a Cause of Kidney Failure: Case Report |
title_sort | hypercalcemia as a cause of kidney failure: case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908746/ https://www.ncbi.nlm.nih.gov/pubmed/27335601 http://dx.doi.org/10.3889/oamjms.2016.044 |
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