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A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway

BACKGROUND: This study was designed to determine the role of the A1 adenosine receptors in intracerebral hemorrhage (ICH)-induced secondary brain injury and the underlying mechanisms. METHODS: A collagenase-induced ICH model was established in Sprague–Dawley rats, and cultured primary rat cortical n...

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Detalles Bibliográficos
Autores principales: Zhai, Weiwei, Chen, Dongdong, Shen, Haitao, Chen, Zhouqing, Li, Haiying, Yu, Zhengquan, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908780/
https://www.ncbi.nlm.nih.gov/pubmed/27301321
http://dx.doi.org/10.1186/s13041-016-0247-x