A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is associated with a high risk for liver cirrhosis and cancer. Recent studies demonstrate that NAFLD significantly impacts on the genome wide methylation and expression reporting top hit genes to be associated with e.g. diabetes mellitus. In a ta...

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Detalles Bibliográficos
Autores principales: Schiöth, Helgi B., Boström, Adrian, Murphy, Susan K., Erhart, Wiebke, Hampe, Jochen, Moylan, Cynthia, Mwinyi, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908840/
https://www.ncbi.nlm.nih.gov/pubmed/27301979
http://dx.doi.org/10.1186/s12864-016-2814-z

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